Evidence map›Paper›PMID 40827033›Full record

ArticlePediatric blood & cancer2025

Life Milestone Achievement Among Young Adult Childhood Cancer Survivors: A Population-Based Cohort and Matched Case-Control Study.

Yoonji Kim, Michael A Hoyt, Michelle Fortier, Joel Milam

Abstract read
In one paragraph

Article in Pediatric blood & cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Yoonji KimDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Michael A HoytDepartment of Population Health and Disease Prevention, Joe C. Wen School of Population & Public Health, University of California, Irvine, California, USA.
Michelle FortierDepartment of Population Health and Disease Prevention, Joe C. Wen School of Population & Public Health, University of California, Irvine, California, USA.
Joel MilamDepartment of Epidemiology and Biostatistics, Joe C. Wen School of Population & Public Health, University of California, Irvine, California, USA.ORCID https://orcid.org/0000-0001-9489-8015

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4M
Reducing racial/ethnic inequities in childhood cancer survivorshipR01MD007801 · NIMHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MILAM, JOEL E · 2014 to 2018
$2.1M
National Institute on Minority Health and Health Disparities at the National Institutes of Health 1R01MD007801NCI NIH HHS P30 CA014089NCI NIH HHS P30CA014089NIMHD NIH HHS R01 MD007801Tobacco-Related Disease Research Program 28IR-0052
6 · The paper itself

Abstract

backgroundYoung adult childhood cancer survivors (YACCS) experience persistent challenges that could delay their transition to independent adulthood. This study examined disparities in life milestone achievement between YACCS and a matched population-based control group and assessed the impact of clinical and demographic factors, including time since diagnosis, treatment intensity, and race/ethnicity.

methodsThis matched case-control study utilized data from Project Forward and the California Health Interview Survey. YACCS were matched to general population controls at a 1:3 ratio based on age, sex, year of survey, and race/ethnicity. Multivariable logistic regression models were used to compare life milestone achievement between the groups and to examine associations between survivor characteristics and life milestone achievement, adjusting for neighborhood socioeconomic status.

resultsThe study included 1106 YACCS and 3292 matched controls. YACCS were less likely to attain a college degree (OR = 0.79, 95% CI: 0.66-0.95), be employed full-time (OR = 0.39, 95% CI: 0.33-0.45), or be married/partnered (OR = 0.69, 95% CI: 0.58-0.82). Conversely, they were more likely to be unemployed (OR = 1.89, 95% CI: 1.61-2.23), work part-time (OR = 1.67, 95% CI: 1.38-2.02), and live with a parent (OR = 3.34, 95% CI: 2.78-4.00). Long-term survivors (15+ years) and those who received more intensive treatments continue to encounter difficulties, particularly with achieving independent living and securing stable employment.

conclusionsYACCS experience significant delays in achieving key life milestones compared to their peers, highlighting the lasting socioeconomic impact of childhood cancer. Intensive treatments further exacerbate these disparities. Targeted interventions and survivorship support programs are needed to address these challenges and improve long-term outcomes.

Indexed as

Cancer SurvivorsNeoplasmsAdolescentAdultCaliforniaCase-Control StudiesChildFemaleFollow-Up StudiesHumansMalePrognosisYoung Adultlife milestone achievementsmatched case–control studyyoung adult childhood cancer survivors

Identifiers

PMID40827033
PMCPMC12863246

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