Evidence map›Paper›PMID 40827001›Full record

ArticleJournal of biochemical and molecular toxicology2025

Common Food Additives Inhibit Carbonic Anhydrase Activity.

Ayça Aktaş Karaçelik, Murat Küçük, Semra Alkan Türkuçar, Şükrü Beydemir

Abstract read
In one paragraph

Article in Journal of biochemical and molecular toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ayça Aktaş KaraçelikDepartment of Food Processing, Espiye Vocational School, Giresun University, Giresun, Turkey.ORCID https://orcid.org/0000-0001-5381-2924
Murat KüçükDepartment of Chemistry, Faculty of Sciences, Karadeniz Technical University, Trabzon, Turkey.ORCID https://orcid.org/0000-0002-1669-5797
Semra Alkan TürkuçarDepartment of Nutrition and Dietetics, Faculty of Health Sciences, Alanya Alaaddin Keykubat University, Alanya, Antalya, Turkey.ORCID https://orcid.org/0000-0002-7763-3880
Şükrü BeydemirDepartment of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.ORCID https://orcid.org/0000-0003-3667-6902

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Few studies about the effects of food additives on human enzymes exist. The effects of 20 food additives (12 colorants, 2 antioxidants, 3 sweeteners, 2 preservatives, and 1 acidity regulator) on bovine carbonic anhydrase (bCA) and especially human isoenzymes hCAI and hCAII isoenzyme, a highly vital enzyme, were studied for the first time. All the additives showed inhibition on human CA isoenzymes with IC

Indexed as

Carbonic Anhydrase ICarbonic Anhydrase IICarbonic Anhydrase InhibitorsCarbonic AnhydrasesFood AdditivesAnimalsAntioxidantsCattleHumansAntioxidantsCarbonic Anhydrase ICarbonic Anhydrase IICarbonic Anhydrase InhibitorsCarbonic AnhydrasesFood AdditivesADMETcarbonic anhydraseenzyme inhibitionerythrosin Bfood additives

Identifiers

PMID40827001
PMCPMC12361874

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.