ReviewClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Coagulation Abnormalities in Lung Cancer: Diagnostic Challenges and Therapeutic Perspectives.
Review in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Diagnostic importance of serum markers in lung cancer.Molecular medicine reports · 2026Article
- Identification of novel ceRNA networks associated with system hemostasis and their prognostic implication in lung squamous cell carcinoma.Journal of thrombosis and thrombolysis · 2026Article
- Risk factor analysis and prediction of lower-extremity deep vein thrombosis after surgery in patients with non-small cell lung cancer.Frontiers in oncology · 2026Article
- Development and validation of a machine-learning-based triage model incorporating systemic inflammatory, nutritional, coagulation, and tumor marker parameters for identifying baseline distant metastasis in lung cancer.Frontiers in oncology · 2026Article
- Dynamic changes in D-dimer during first-line therapy and their association with overall survival in advanced lung cancer: a retrospective study.American journal of cancer research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lung cancer is frequently complicated by coagulation abnormalities, primarily presenting as venous thromboembolism (VTE) but also including bleeding events in select patients. This hypercoagulable state arises from a multifaceted interplay between tumor-derived procoagulants, systemic inflammation, endothelial dysfunction, autoimmune mechanisms, and treatment-associated effects. These disruptions not only elevate thrombotic risk but also influence prognosis and therapeutic decisions. Furthermore, the presence of antiphospholipid antibodies or acquired coagulation inhibitors, such as lupus anticoagulant and anti-Factor VIII antibodies, poses a unique clinical challenge by increasing the risk of both thrombosis and hemorrhage. Recent data highlight the expanding role of tumor-derived extracellular vesicles, immune-mediated coagulopathies, and prothrombotic effects of immune checkpoint inhibitors in lung cancer-associated thrombosis. Novel biomarkers-such as prothrombin fragment 1 + 2, integrin β2- positive extracellular vesicles, and endothelial activation markers-are being investigated for risk stratification and personalized treatment decisions. Diagnostic approaches-including coagulation assays, biomarker profiling, and imaging-are discussed alongside emerging tools for individualized anticoagulation and management of acquired inhibitors. Early recognition and tailored management of cancer-associated coagulopathy are essential to improve patient outcomes. This review aims to provide practical insights for clinicians navigating the thrombohemorrhagic spectrum in lung cancer care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.