Evidence map›Paper›PMID 40826487›Full record

ArticleJournal of intensive care2025

Optimal timing for assessing post-intensive care syndrome in clinical research: a scoping review and expert survey.

Kohei Tanaka, Nobuto Nakanishi, Keibun Liu, Kyohei Miyamoto, Akira Kawauchi, Masatsugu Okamura, Sho Katayama, Yuki Iida, Yusuke Kawai, Junji Hatakeyama and 18 more

Abstract read
In one paragraph

Article in Journal of intensive care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Kohei TanakaDepartment of Rehabilitation Medicine, Osaka International Medical & Science Center, 2-6-40 Karasugatsuji, Tennoji-Ku, Osaka, 543-8922, Japan.
Nobuto NakanishiDivision of Disaster and Emergency Medicine, Department of Surgery Related, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-Cho, Chuo-Ku, Kobe, 650-0017, Japan. nobuto_nakanishi@yahoo.co.jp.
Keibun LiuNon-Profit Organization ICU Collaboration Network (ICON), 2-15-13 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Kyohei MiyamotoDepartment of Emergency and Critical Care Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama, Wakayama, 641-8509, Japan.
Akira KawauchiDepartment of Critical Care and Emergency Medicine, Japanese Red Cross Maebashi Hospital, 389-1 Asakura-Machi, Maebashi, Gunma, 371-0811, Japan.
Masatsugu OkamuraBerlin Institute of Health Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Sho KatayamaDepartment of Rehabilitation Medicine, Okayama University Hospital, 2-5-1 Shikata, Kitaku, Okayama, 700-8558, Japan.
Yuki IidaDepartment of Physical Therapy, School of Health Sciences, Aichi Shukutoku University, 2-9 Katahira, Nagakute, 480-1197, Japan.
Yusuke KawaiDepartment of Nursing, Fujita Health University Hospital, 1-98 Dengakugakubo, Kutsukake-Cho, Toyoake, Aichi, 470-1192, Japan.
Junji HatakeyamaDepartment of Emergency and Critical Care Medicine, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-Machi, Takatsuki, Osaka, 569-8686, Japan.
Toru HifumiDepartment of Emergency and Critical Care Medicine, St. Luke's International Hospital, 9-1 Akashi-Cho, Chuo-Ku, Tokyo, 104-8560, Japan.
Takeshi UnokiDepartment of Acute and Critical Care Nursing, School of Nursing, Sapporo City University, Kita 11 Nishi 13, Chuo-Ku, Sapporo, 060-0011, Japan.
Daisuke KawakamiDepartment of Intensive Care Medicine, Iizuka Hospital, 3-83 Yoshio-Machi, Iizuka, Fukuoka, 820-8505, Japan.
Fumimasa AmayaDepartment of Pain Management and Palliative Care Medicine, Kyoto Prefectural University of Medicine, 465 Kajii-Cho, Kawaramachi-Hirokoji, Kamigyo-Ku, Kyoto, 602-8566, Japan.
Kengo ObataDepartment of Rehabilitation, Japanese Red Cross Okayama Hospital, 2-1-1 Aoe, Kita-Ward, Okayama, 700-8607, Japan.
Hidenori SumitaClinic Sumita, 305-12 Minamiyamashinden, Ina-Cho, Toyokawa, Aichi, 441-0105, Japan.
Tomoyuki MorisawaDepartment of Rehabilitation, Kobe Rehabilitation Hospital, 1-18 Shiawasenomura, Kita-Ku, Kobe, 651-1106, Japan.
Norihiko TsuboiDepartment of Critical Care and Anesthesia, National Center for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo, 157-8535, Japan.
Ryo KozuDepartment of Rehabilitation Medicine, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Shunsuke TakakiDepartment of Critical Care Medicine, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-Ku, Yokohama, Kanagawa, 236-0004, Japan.
Junpei HarunaDepartment of Intensive Care Medicine, School of Medicine, Sapporo Medical University, South-1, West-16, Chuo-Ku, Sapporo, Hokkaido, 060-8543, Japan.
Kohei OtaDepartment of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
Yoshihisa FujinamiDepartment of Emergency Medicine, Kakogawa Central City Hospital, 439 Kakogawacho Honmachi, Kakogawa-City, Hyogo, 675-8611, Japan.
Nobuyuki NosakaDepartment of Intensive Care Medicine, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, 113-8510, Japan.
Kasumi ShirasakiDepartment of Emergency and Critical Care Medicine, St. Luke's International Hospital, 9-1 Akashi-Cho, Chuo-Ku, Tokyo, 104-8560, Japan.
Shigeaki InoueDepartment of Emergency and Critical Care Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama, Wakayama, 641-8509, Japan.
Osamu NishidaDepartment of Anesthesiology and Critical Care Medicine, School of Medicine, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-Cho, Toyoake, Aichi, 470-1192, Japan.
Kensuke NakamuraDivision of Disaster and Emergency Medicine, Department of Surgery Related, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-Cho, Chuo-Ku, Kobe, 650-0017, Japan.

Funding

Japan Society for the Promotion of Science JP24K19491
6 · The paper itself

Abstract

backgroundSince the concept of post-intensive care syndrome (PICS) was proposed, numerous studies have assessed patients and their family members. However, a wide range of assessment timings has been employed across previous studies. This study aimed to clarify how assessment timings have been implemented in existing PICS research through a scoping review, and to explore expert opinions on optimal assessment timing via an online survey.

methodsWe conducted a scoping review of studies assessing PICS-related outcomes, including physical, cognitive, and psychological impairments, as well as PICS in family members. Studies were retrieved from MEDLINE, CENTRAL, and CINAHL, and screened by two independent pairs of reviewers. Eligible studies were published between January 2014 and December 2022. Studies lacking a clear description of assessment timing were excluded. We analyzed the reference point used to determine assessment schedules, the assessment time points, and their frequency. Additionally, an online questionnaire was administered to 23 members of the Japanese Society of Intensive Care Medicine PICS committee and working group members to collect expert opinions on these three aspects for clinical research.

resultsA total of 657 studies were included. In prior studies, hospital discharge was the most commonly used reference point for determining assessment schedule (240 studies, 40%). However, ICU discharge was identified by experts as the ideal reference point (16 votes, 47%). The most frequently used assessment time points were 3 months (262, 23%), 6 months (212, 19%), and 12 months (206, 18%) post-discharge. Experts most commonly selected the period between 6 and 12 months as the optimal time point for assessment. While single assessments were most common in previous studies (337, 51%), experts considered three assessments to be ideal (12, 44%).

conclusionsThis study revealed notable discrepancies between the assessment timing reported in previous studies and the opinions of experts regarding optimal timing. Standardization of assessment timing in PICS research is warranted to enhance methodological consistency and comparability.

Indexed as

Cognitive functionCritical illnessFamilyIntensive care unitMental healthPhysical function

Identifiers

PMID40826487
PMCPMC12359912

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.