Evidence map›Paper›PMID 40826460›Full record

ArticleJournal of translational medicine2025

AAV-mediated STC-1 expression mitigates neuroinflammation and preserves visual function in degenerative retinopathy.

Yange Wang, Siyu Li, Chenxu Zhang, Miao Li, Kexin Wang, Gang Wang, Ye Tao, Zongming Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yange Wang *Department of Ophthalmology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Henan Eye Hospital and Henan Key Laboratory of Ophthalmology and Visual Science, Zhengzhou, 450003, China.ORCID 0000-0001-7216-7430
Siyu Li *Department of Ophthalmology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Henan Eye Hospital and Henan Key Laboratory of Ophthalmology and Visual Science, Zhengzhou, 450003, China.
Chenxu ZhangDepartment of Ophthalmology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Henan Eye Hospital and Henan Key Laboratory of Ophthalmology and Visual Science, Zhengzhou, 450003, China.
Miao LiDepartment of Ophthalmology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Henan Eye Hospital and Henan Key Laboratory of Ophthalmology and Visual Science, Zhengzhou, 450003, China.
Kexin WangDepartment of Ophthalmology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Henan Eye Hospital and Henan Key Laboratory of Ophthalmology and Visual Science, Zhengzhou, 450003, China.
Gang WangDepartment of Ophthalmology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Henan Eye Hospital and Henan Key Laboratory of Ophthalmology and Visual Science, Zhengzhou, 450003, China.
Ye TaoDepartment of Ophthalmology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Henan Eye Hospital and Henan Key Laboratory of Ophthalmology and Visual Science, Zhengzhou, 450003, China. panghtoyezz@zzu.edu.cn.
Zongming SongDepartment of Ophthalmology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Henan Eye Hospital and Henan Key Laboratory of Ophthalmology and Visual Science, Zhengzhou, 450003, China. smeyes@zzu.edu.cn.

Funding

Key Research and Development and Promotion Project of Henan Province 222102310061Major science and technology special projects of Henan Province 221100310200National Natural Science Foundation of China 82101162Provincial Co-construction Project of Medical Science and Technology Plan of Henan Province SBGJ202402092
6 · The paper itself

Abstract

backgroundRetinal degeneration (RD) is a chronic retinopathy that characterized by the progressive photoreceptor apoptosis and visual impairments. However, due to the complicated pathogenesis of RD, there is no effective treatment at present. This study intends to verify the therapeutic effect and mechanism of stanniocalcin-1 (STC-1) in the sodium iodate (NaIO

methodsThe pAAV2/8-Stc1 vector was established and delivered into the vitreous cavity of RD mouse model. Subsequently, these treated mice were subjected to a series of functional and morphological assay.

resultsPervasive neuroinflammation reaction and oxidative stress occurred in the retinas of RD model. Intravitreal injection of pAAV2/8-Stc1 vector enabled the stable STC-1 expression in the retinas. AAV-mediated STC-1 overexpression could preserve the retinal structure and enhance the photoreceptor survival effectively. Fundus photography showed the distribution of retinal vessel was clear, and the severity of lesions was relieved. Particularly, these morphological benefits could yield significant improvements in visual functionality, as evidenced by both behavioral tests and multifocal electroretinogram (mf-ERG) evaluations. Mechanism study showed that STC-1 alleviated the oxidative stress, inhibited the neuroglia activation, and mitigated the release of pro-inflammatory cytokines through CX3CL1/CX3CR1/NF-κB axis.

conclusionsThis research unveils a robust correlation between the photoreceptor vitality and the STC-1 expression in RD model. The AAV mediated STC-1 over-expression can be developed into a promising therapeutic approach for degenerative retinopathy.

Indexed as

DependovirusGlycoproteinsNeuroinflammatory DiseasesRetinal DegenerationVision, OcularAnimalsCytokinesDisease Models, AnimalGenetic VectorsInflammationIodatesMaleMiceMice, Inbred C57BLOxidative StressRetinaCytokinesGlycoproteinsIodatesteleocalcinBehaviorOxidative stressRetinal degenerationVisual function

Identifiers

PMID40826460
PMCPMC12359868

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.