ArticleJournal of translational medicine2025
Single-cell transcriptomic analysis reveals metastatic and immunosuppressive characteristics in meningioma brain-tumor interface.
Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Tumor location and morphological MRI features in relation to combined 1p/22q deletion in meningioma.Discover oncology · 2026Article
- Leveraging single-cell and spatial omics for brain tumour insights to improve therapeutic strategies.Molecular brain · 2026Review
- Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single-Cell and Spatial Transcriptomics.Annals of clinical and translational neurology · 2026Article
- Peritumoral edema in meningiomas: a review of influencing factors, mechanisms, and management.Frontiers in oncology · 2026Review
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Authors and funding
11 authors.
Funding
Abstract
backgroundMeningioma is a common primary intracranial tumor with high recurrence and metastasis rate. Delineating the pathological ecosystem at the brain-tumor interface (BTI) of meningioma is critical for understanding the mechanisms of tumor metastasis and developing effective new therapies.
methodsTo identify biomarkers of early metastasis and discover potential therapeutic targets, we integrated single-cell transcriptome datasets of meningioma, and identified the cell populations and molecular signatures uniquely present at the BTI.
resultsA specific BTI-enriched tumor cell population with a pro-EMT (epithelial mesenchymal transition) characteristics was associated with invasion and metastasis, and ANXA2 and COL5A1 were detected as the biomarkers for these BTI-enriched tumor cells. Additionally, we characterized the BTI-specific immunosuppressive microenvironment composed of SPP1
conclusionsCollectively, BTI in meningioma is a metastatic and immunosuppressive zone. We have discovered potential biomarkers that help detect early metastasis and recurrence of meningioma.
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