Evidence map›Paper›PMID 40826453›Full record

ArticleBMC oral health2025

The comparison of physicochemical and bioactivity properties of different nanoparticles modified calcium silicate-based cement.

Silsupa Saingern, Naruporn Monmaturapoj, Chanakarn Sinsareekul, Porawit Kamnoedboon, Thanaphum Osathanon, Murali Srinivasan, Pavena Chivatxaranukul, Thawanrat Singthong, Chalermkwan Makornpan, Dusit Nantanapiboon

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Silsupa SaingernDepartment of Operative Dentistry, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
Naruporn MonmaturapojMaterials Technology Center (MTEC), National Metaland, National Science and Technology Development Agency , Pathum Thani, Thailand.
Chanakarn SinsareekulIntercollaborative Endodontics and Engineering Research Group, Department of Operative Dentistry, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
Porawit KamnoedboonClinic of General, Special Care, and Geriatric Dentistry, Center for Dental Medicine, University of Zurich, Zurich, Switzerland.
Thanaphum OsathanonCenter of Excellence for Dental Stem Cell Biology and Department of Anatomy, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
Murali SrinivasanClinic of General, Special Care, and Geriatric Dentistry, Center for Dental Medicine, University of Zurich, Zurich, Switzerland.
Pavena ChivatxaranukulIntercollaborative Endodontics and Engineering Research Group, Department of Operative Dentistry, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
Thawanrat SingthongDental Materials Research and Development Center, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
Chalermkwan MakornpanMaterials Technology Center (MTEC), National Metaland, National Science and Technology Development Agency , Pathum Thani, Thailand.
Dusit NantanapiboonDepartment of Operative Dentistry, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand. Dusit.n@chula.ac.th.

Funding

Faculty of Dentistry, Chulalongkorn University DRF 68_018
6 · The paper itself

Abstract

backgroundTo investigate the effects of adding ZrO₂, TiO₂, and two sizes of hydroxyapatite (HAP) nanoparticles on the physicochemical and bioactivity properties of calcium silicate-based cement (CSC).

methodsMTA, PC, and nanoparticle-modified groups (5% and 10% n-ZrO₂, n-TiO₂, n-HAP1, n-HAP2) were evaluated for setting time, compressive strength (1, 7, 14 days), solubility (14 days), and bioactivity. Setting time and compressive strength followed ISO 9917-1:2007, solubility followed a modified ISO 6876:2012, and bioactivity was analyzed using SEM-EDS.

resultsAll groups showed significantly reduced setting times (p < 0.001) compared to MTA and PC, with 10% n-HAP1 showing the greatest reduction. Compressive strength increased over time in all groups except 5% and 10% n-ZrO₂, which remained stable (p > 0.05). MTA had the highest strength at 14 days. MTA's solubility was higher than PC's (p < 0.001). All groups, except 10% n-TiO₂, 5% and 10% n-HAP1, showed increased solubility vs. MTA (p < 0.003); all exceeded PC (p < 0.001). SEM after 1 day showed spherical apatite structures, which thickened by days 7 and 14. EDS confirmed Ca/P ratios similar to controls.

conclusionsAll nanoparticles accelerated the setting time, and only ZrO₂ nanoparticles enhanced early strength. Despite increased solubility, all values remained within acceptable limits. All groups demonstrated bioactivity potential.

Indexed as

Calcium CompoundsDental CementsNanoparticlesRoot Canal Filling MaterialsSilicatesAluminum CompoundsBiocompatible MaterialsChemical PhenomenaCompressive StrengthDrug CombinationsDurapatiteHumansMaterials TestingMicroscopy, Electron, ScanningOxidesParticle SizeAluminum CompoundsBiocompatible MaterialsCalcium Compoundscalcium silicateDental CementsDrug CombinationsDurapatitemineral trioxide aggregateOxidesRoot Canal Filling MaterialsSilicatesTitaniumtitanium dioxideZirconiumzirconium oxideBioactivity propertiesCalcium silicate-based cementHealth issuesModified-calcium silicate-based cementNanoparticlesPhysicochemical properties

Identifiers

PMID40826453
PMCPMC12362959

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.