Evidence map›Paper›PMID 40826430›Full record

ArticleJournal of translational medicine2025

Establishment and evaluation of a patient-derived organoids-based xenograft model of primary aldosteronism using [

Xuezhou Zhang, Tiantian Mou, Yuxuan Wang, Qi Miao, Wei Wang, Zhipeng Sun, Yuxuan Bo, Jiayuan Cui, Jiahui Zhao, Mingchuan Li and 3 more

Abstract read
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In one paragraph

Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xuezhou Zhang *Department of Urology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Tiantian Mou *Department of Nuclear Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Yuxuan Wang *Department of Urology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Qi MiaoDepartment of Urology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Wei WangDepartment of Urology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Zhipeng SunDepartment of Urology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Yuxuan BoDepartment of Urology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Jiayuan CuiDepartment of Urology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Jiahui ZhaoDepartment of Urology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Mingchuan LiDepartment of Urology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Baoan HongDepartment of Urology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China. hbaurology@bjmu.edu.cn.
Hongzhi MiDepartment of Nuclear Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China. im3256@sina.com.
Ning ZhangDepartment of Urology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China. Azurology_zn@126.com.ORCID 0009-0009-8108-6910

Funding

Beijing Anzhen Hospital High Level Research Funding 2024AZC3001
6 · The paper itself

Abstract

backgroundPrimary aldosteronism (PA) is a leading cause of secondary hypertension, but the lack of representative preclinical models hampers translational research and imaging evaluation. We aimed to establish a patient-derived organoids-based xenograft (PDOX) model of PA and to assess its imaging characteristics using [

methodsAdrenal tissues from patients with PA were used to generate adrenal organoids in vitro. After serial passaging, these organoids were implanted subcutaneously into immunodeficient mice to establish PA PDOX models. The xenografted mice were subjected to [

resultsThe PDOX models successfully engrafted and proliferated in vivo, maintaining key pathological features of PA. [

conclusionWe established a novel PDOX model of PA and demonstrated the effectiveness of [

Indexed as

Fluorine RadioisotopesHeterocyclic CompoundsHeterocyclic Compounds, 1-RingHyperaldosteronismOrganoidsPositron Emission Tomography Computed TomographyAnimalsDisease Models, AnimalFemaleHeterograftsHumansMaleMiceMiddle Aged1,4,7-triazacyclononane-N,N',N''-triacetic acidFluorine RadioisotopesHeterocyclic CompoundsHeterocyclic Compounds, 1-Ring[18F]AlF-NOTA-pentixather PET/CTOrganoidsPDOX modelPrimary aldosteronism

Identifiers

PMID40826430
PMCPMC12363005

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.