ArticleJournal of nanobiotechnology2025
Imogolite nanotube modifications impact pulmonary toxicity in mice: implications for safe and sustainable by design (SSbD).
Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Novel Carbon Dots Nanomaterials for the Precision Diagnosis and Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome: Mechanisms and Applications.International journal of nanomedicine · 2026Review
- Comparison of Lung Inflammatory and Transcriptional Responses in Mice and Rats Following Pulmonary Exposure to a Fiber Paradigm-Compatible and Non-Compatible MWCNT.Nanomaterials (Basel, Switzerland) · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundImogolite is a naturally occurring hollow aluminosilicate nanotube with potential for engineered applications due to its high aspect ratio, hydrophilicity, and polarization. However, these same features raise concerns about potential adverse health effects. These concerns parallel those associated with multi-walled carbon nanotubes (MWCNTs), which are known to cause inflammation, fibrosis, and cardiovascular effects. The purpose of this study was to investigate how surface functionalization of imogolite influences its toxicity and biological response, with the aim of informing safer design of nanomaterials. Female C57BL/6J mice were exposed via intratracheal instillation to 6, 18, or 54 µg of hydroxylated (Imo-OH) or methylated (Imo-CH
resultsPhysicochemical characterization showed that Imo-OH dispersed as single nanotubes, while Imo-CH
conclusionsBoth imogolite variants induced pulmonary inflammation and an acute-phase response in mice; however, these effects were markedly reduced for the methylated imogolite (Imo-CH
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