ArticleAesthetic plastic surgery2025
Autologous Fat Granules Combined with PRP Treat Hypertrophic Scars Through TGF-β/Smad Signaling Pathway.
Article in Aesthetic plastic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Mechanism of Platelet-Rich Plasma in Promoting Diabetic Wound Healing via the PI3K/AKT Signaling Pathway to Regulate Collagen Synthesis and Angiogenesis.Journal of diabetes research · 2026Article
- Platelet-rich therapies in cutaneous and mucocutaneous disorders characterized by inflammatory tissue responses: mechanistic insights and clinical evidence.Frontiers in medicine · 2026Review
- Platelet-Rich Plasma (PRP) bidirectionally modulates scar formation via the Piezo1-YAP/TAZ axis: a novel mechanotransduction hypothesis.Frontiers in cell and developmental biology · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
objectiveHypertrophic scars (HS) are the result of abnormal tissue repair after dermal tissue trauma. Their histological characteristics are fibroblast proliferation and excessive deposition of extracellular matrix. This study aimed to identify the role of autologous fat granule (AFG) combined with platelet-rich plasma (PRP) in HS formation and its possible mechanism through in vivo experiments.
methodsA rat wound healing HS model was established, and AFG and PRP alone or in combination treated HS model rats. After 8 weeks of intervention, HS tissues were collected for HE staining, VG staining, immunohistochemistry, ELISA and Western blot analysis.
resultsAFG treatment could significantly inhibit angiogenesis and hypertrophic scar proliferation in HS tissue, and reduce collagen fiber content and inflammatory cell infiltration, and the above changes were more significant when combined with PRP treatment, indicating that AFG combined with PRP treatment had a better therapeutic effect in HS animal model. In addition, AFG treatment can significantly reduce the expression of TGFBRI and Smad3 proteins in HS tissues, and compared with AFG alone, AFG combined with PRP treatment can further reduce the expression of TGFBRI and Smad3 proteins in HS tissues.
conclusionAFG combined with PRP can reduce inflammatory cell infiltration and collagen fiber content in HS tissue, and inhibit angiogenesis and scar proliferation, which may be related to inhibiting the activation of TGF-β/Smad signaling pathway. Our study provides a reference for the clinical treatment of HS. NO LEVEL ASSIGNED: No level of evidence is needed for Basic Science, Animal Study, and Experimental Study Articles. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
Indexed as
Identifiers
40826296What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.