Evidence map›Paper›PMID 40826283›Full record

ArticleMolecular psychiatry2026

Pathogenic microbiota disrupts the intact structure of cerebral organoids by altering energy metabolism.

Melis Isik, Cemil Can Eylem, Kubra Erdogan-Gover, Pinar Aytar-Celik, Blaise Manga Enuh, Emel Emregul, Ahmet Cabuk, Yalin Yildirim, Emirhan Nemutlu, Alysson Renato Muotri and 1 more

Abstract read
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In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Melis IsikStem Cell Research Lab, Department of Chemistry, Faculty of Science, Ankara University, Ankara, Türkiye.
Cemil Can EylemAnalytical Chemistry Division, Faculty of Pharmacy, Hacettepe University, Ankara, Türkiye.
Kubra Erdogan-GoverDepartment of Biotechnology and Biosafety, Graduate School of Natural and Applied Science, Eskisehir Osmangazi University, Eskisehir, Türkiye.
Pinar Aytar-CelikDepartment of Biotechnology and Biosafety, Graduate School of Natural and Applied Science, Eskisehir Osmangazi University, Eskisehir, Türkiye.
Blaise Manga EnuhGreat Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Emel EmregulStem Cell Research Lab, Department of Chemistry, Faculty of Science, Ankara University, Ankara, Türkiye.
Ahmet CabukDepartment of Biotechnology and Biosafety, Graduate School of Natural and Applied Science, Eskisehir Osmangazi University, Eskisehir, Türkiye.
Yalin YildirimDepartment of Cardiovascular Surgery, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Emirhan NemutluAnalytical Chemistry Division, Faculty of Pharmacy, Hacettepe University, Ankara, Türkiye.
Alysson Renato MuotriDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Burak DerkusStem Cell Research Lab, Department of Chemistry, Faculty of Science, Ankara University, Ankara, Türkiye. bderkus@ankara.edu.tr.ORCID http://orcid.org/0000-0001-5558-0995

Funding

Türkiye Bilimsel ve Teknolojik Araştirma Kurumu (Scientific and Technological Research Council of Turkey) 219S661
6 · The paper itself

Abstract

This study investigated the impact of different bacterial populations on the biomolecular structures of cerebral organoids (COs) at various levels. COs were co-cultured with non-pathogenic (NM) and pathogenic (PM) bacterial populations. PM reduced the number of TUJ1+ neurons and disrupted the intact structure of COs. In addition, PM was found to induce changes in the transcript profile of COs, including a decrease in the activity of the glycolysis pathway and an increase in the pentose phosphate pathway, leading to deterioration in cellular energy metabolism, which is linked to neurodegenerative diseases. Proteomic analysis revealed a unique cluster of proteins in COs. PM exposure upregulated proteins related to neurological diseases, consistent with RNA-seq data. Communication between bacteria and neural cells was demonstrated using

Indexed as

Energy MetabolismMicrobiotaOrganoidsAnimalsBacteriaBrainCoculture TechniquesGlycolysisHumansNeurodegenerative DiseasesNeuronsProteomics

Identifiers

PMID40826283

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.