ArticleScientific reports2025
Lymph node transcriptomic profiles suggest susceptibility to bleomycin-induced pulmonary toxicity in classic hodgkin lymphoma.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Despite advances in reducing treatment-related toxicities, predictive biomarkers for bleomycin-induced pulmonary toxicity (BPT) remain undefined. Affecting around 10% of classic Hodgkin lymphoma (CHL) and associated with a mortality rate of 10-20%, BPT poses a clinical challenge. This study aimed to characterize the pre-therapeutic nodal tumor microenvironment in CHL patients with and without BPT development. Gene expression profiling (GEP) was performed on diagnostic lymph node biopsies from CHL patients who developed BPT (T-CHL, n = 23) during treatment and those who did not (nT-CHL, n = 47). Differential protein expression of MIF, pSTAT3, LILRB3, and CD206 was further assessed with immunohistochemistry (IHC) in an evaluation cohort (n = 285). GEP revealed T-CHL samples enriched in genes associated with immune regulation and inflammation (STAT3, LILRB3, MIF), fibrosis and tissue remodeling (CD206), and immune signaling and regulation of apoptosis (JAK3) compared with nT-CHL. IHC confirmed higher pSTAT3 (p = 0.001) and CD206 (p = 0.029) expression in T-CHL and lower MIF and LILRB3 expression (both p < 0.001) compared with nT-CHL. These findings suggest that immune and fibrotic signatures in diagnostic biopsies may predict BPT risk. Early identification of high-risk patients could enable personalized treatment approaches that reduce toxicity while maintaining efficacy, positioning tumor microenvironment profiling as a promising strategy for optimizing CHL care.
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