Evidence map›Paper›PMID 40826175›Full record

ReviewNature reviews. Chemistry2025

Steering towards safe self-driving laboratories.

Shi Xuan Leong, Caleb E Griesbach, Rui Zhang, Kourosh Darvish, Yuchi Zhao, Abhijoy Mandal, Yunheng Zou, Han Hao, Varinia Bernales, Alán Aspuru-Guzik

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
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  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shi Xuan LeongDepartment of Chemistry, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-8130-0897
Caleb E Griesbach *Department of Chemistry, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-6969-4851
Rui Zhang *Department of Chemistry, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-7396-7165
Kourosh Darvish *Acceleration Consortium, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-4984-432X
Yuchi Zhao *Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0009-0006-5419-4391
Abhijoy MandalDepartment of Computer Science, University of Toronto, Toronto, Ontario, Canada.
Yunheng ZouDepartment of Computer Science, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0009-0007-9131-4468
Han HaoDepartment of Chemistry, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-0176-3929
Varinia BernalesDepartment of Chemistry, University of Toronto, Toronto, Ontario, Canada. varinia@bernales.org.ORCID http://orcid.org/0000-0002-8446-7956
Alán Aspuru-GuzikDepartment of Chemistry, University of Toronto, Toronto, Ontario, Canada. alan@aspuru.com.ORCID http://orcid.org/0000-0002-8277-4434

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The past decade has witnessed remarkable advancements in autonomous systems, such as automobiles that are evolving from traditional vehicles to ones capable of navigating complex environments without human intervention. Similarly, the rise of self-driving laboratories (SDLs), which leverage robotics and artificial intelligence to accelerate discovery, is driving a paradigm shift in scientific research. As SDLs evolve to expand the scope of chemical processes that can be performed, it is essential to bring safety to the forefront to ensure that the necessary safeguards are in place to mitigate against potential accidents that range from near-misses to catastrophic failures. This Perspective examines the development trajectory of SDLs, juxtaposing their development with those of other autonomous technologies, with a particular focus on safety. We explore current safety status and concerns, identify opportunities for innovation to shape this rapidly evolving landscape, and reflect on the actions the SDL community can take moving forward.

Identifiers

PMID40826175

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.