Evidence map›Paper›PMID 40826141›Full record

ArticleBMC research notes2025

Telomere length measures in the Northern Ireland cohort for the longitudinal study of ageing (NICOLA).

Claire Hill, Laura Smyth, Jill Kilner, Katie Quinn, Angie Scott, Charlotte Neville, Frank Kee, Bernadette McGuinness, Amy Jayne McKnight

Abstract read
In one paragraph

Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Claire HillCentre for Public Health, Queen's University Belfast, Belfast, UK.
Laura SmythCentre for Public Health, Queen's University Belfast, Belfast, UK.
Jill KilnerCentre for Public Health, Queen's University Belfast, Belfast, UK.
Katie QuinnCentre for Public Health, Queen's University Belfast, Belfast, UK.
Angie ScottCentre for Public Health, Queen's University Belfast, Belfast, UK.
Charlotte NevilleCentre for Public Health, Queen's University Belfast, Belfast, UK.
Frank KeeCentre for Public Health, Queen's University Belfast, Belfast, UK.
Bernadette McGuinnessCentre for Public Health, Queen's University Belfast, Belfast, UK.
Amy Jayne McKnightCentre for Public Health, Queen's University Belfast, Belfast, UK. a.j.mcknight@qub.ac.uk.

Funding

Social Circumstances and Epigenomics Promoting Health in Three CountriesR01AG068937 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CRIMMINS, EILEEN M, FAUL, JESSICA · 2020 to 2025
$2.9M
HSC R&D division STL/5569/19NIA NIH HHS R01 AG068937NIA NIH HHS R01AG068937The Atlantic Philanthropies, the Economic and Social Research Council ES/L0084559/1the Health and Social Care Research and Development Division of the Public Health Agency STL/4717/12UKRI MRC MRC MC_PC_20026Vivensa Foundation PF2502\5Wellcome Trust
6 · The paper itself

Abstract

objectivesUsing blood derived DNA collected from individuals within the Northern Ireland COhort for the Longitudinal study of Ageing (NICOLA), quantitative real-time polymerase chain reaction (RT-PCR) based absolute telomere length measures were derived in triplicate. This data is generated on a subset of participants (n = 2,971) within the NICOLA cohort at Wave 1 baseline. NICOLA commenced Wave 3 of data collection in Autumn 2024. DATA DESCRIPTION: The NICOLA study recruited approximately 8,500 people from across Northern Ireland, with individuals recruited as representative of the Northern Ireland population. At recruitment, the NICOLA cohort was 45% male and 55% female. Adults were recruited over the age of 50, with approximately 50% of participants aged between 50 and 65, and 10% of participants over the age of 80. Telomere length (TL) values were determined for 2,971individuals (47.7% male) across 33 batches using the Absolute Human Telomere Length Quantification qPCR Assay kit and Roche LightCycler 480 II. Within-batch duplicate measures were established, as were water controls and non-template controls.

Indexed as

AgingTelomereTelomere HomeostasisAgedAged, 80 and overCohort StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedNorthern IrelandReal-Time Polymerase Chain ReactionAging; NICOLACohortEpigeneticGeneticMolecularRT-PCRTelomere

Identifiers

PMID40826141
PMCPMC12359945

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.