ArticleBMC plant biology2025
Furanocoumarins in two European species of Heracleum: transcriptomic and metabolomic study.
Article in BMC plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- From Chemical Scaffold to Predicted Toxicity: A Scaffold-Aware Pipeline for Reliable In Silico Prioritization ofInternational journal of molecular sciences · 2026Article
- Chemical Profiling and Anti-Inflammatory Mechanisms ofMetabolites · 2026Article
- Primary and Hepatogenous Photosensitization in Livestock: A Review of Plant-Derived Phototoxins and Veterinary Implications.Veterinary sciences · 2026Review
- Phytochemistry and Allelopathic Properties of InvasivePlants (Basel, Switzerland) · 2026Article
- Analysis of the Toxicological Profile ofPlants (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundSpecies of the Apiaceae family produce furanocoumarins-photosensitizing substances widely used in pharmacology. Among them, certain species of the genus Heracleum, commonly known as "giant hogweeds", are particularly renowned for their photosensitizing properties. While the metabolic composition of these plants has been studied extensively, their genomics remains largely unexplored, as does the biosynthesis of furanocoumarins within the genus. The reasons behind the increased photosensitivity of giant hogweeds compared to other Heracleum species remain unclear.
resultsA comparison of the genomic features and furanocoumarin content of the aboveground organs in two Heracleum species was carried out: H. sosnowskyi, a giant hogweed with strong photosensitizing activity, and H. sibiricum, a non-invasive and "harmless" species. Both species produce all known angular and linear compounds of the furanocoumarin synthesis pathway (from umbelliferone to isopimpinellin). The genomes of both species possess homologues of genes involved in the biosynthesis of both angular and linear furanocoumarins. However, the two species differ significantly in the quantity of those compounds. H. sibiricum synthesizes angular furanocoumarins in a much lower level, probably due to lack of the gene for umbelliferon-8-dimetylallyl transferase enzyme. H. sosnowskyi accumulates significantly higher level of xanthotoxin. Interpopulation differences were observed in both the compound content and the expression level of biosynthetic genes.
conclusionThis study represents the first comparative analysis of genomic and metabolic data for closely related Heracleum species in relation to furanocoumarin biosynthesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.