ArticleNature communications2025
Gene duplication and clustering underlie the conservation and diversification of benzylisoquinoline alkaloid biosynthesis in plants.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Genome-Wide Identification and Functional Verification of CoreInternational journal of molecular sciences · 2026Article
- Genome-Wide Characterization of thePlants (Basel, Switzerland) · 2026Article
- Comparative genomics reveals the evolution of anthraquinone biosynthesis in Polygonaceae.BMC genomics · 2026Article
- Genome-wide identification and alkaline stress response analysis of the class III peroxidase (PRX) gene family in Castanea mollissima.BMC plant biology · 2026Article
- Virtual and CMC-Based Screening Identified Reticuline, an Intermediate of BIA Biosynthesis, as a Potential Agonist of D5R.Molecules (Basel, Switzerland) · 2026Article
- Biosynthesis of benzylisoquinoline alkaloids and its evolution in plants.Plant communications · 2026Review
- Genome-wide identification and characterization of the GRX gene family inFrontiers in plant science · 2026Article
- Herbgenomics: Unraveling natural product biosynthesis in traditional Chinese medicine.Chinese herbal medicines · 2026Article
- A Modular Chemoenzymatic Cascade Simplifies Divergent Synthesis of Natural and Unnatural Benzylisoquinoline Alkaloids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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12 authors.
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Abstract
Benzylisoquinoline alkaloids (BIAs), comprising ~2500 compounds with pharmacological significance, are well-studied in Ranunculales but poorly understood in Magnoliids, an early-diverging angiosperm group. This study characterizes key enzymes in Houttuynia cordata-including 6-OMT, NMT, CYP80B, and 4'OMT-that form BIA backbones and uncovers a CYP80G-mediated phenol coupling reaction in isoboldine biosynthesis. Functional analysis reveals conservation of BIA backbone formation genes between Magnoliids and Ranunculales, with evidence of gene duplication and neofunctionalization in H. cordata. Genome-wide analysis identifies dynamic clustering of CYP80B with 4'OMT and 6-OMT genes across angiosperms, reflecting their interlinked biochemical roles in the formation of BIA backbones. These findings suggest that such gene clustering may evolved through biochemical coordination, offering insights into the evolutionary mechanisms behind plant gene cluster formation. The study provides a foundation for understanding BIA biosynthesis across flowering plants and supports synthetic biology strategies to produce high-value BIAs.
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