ArticleScientific reports2025
To select the optimal immunohistochemical staining method for pigmented melanoma.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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3 authors.
Funding
Abstract
Melanin granules may be difficult to distinguish from the brown reaction product of 3,3'-diaminobenzidine (DAB) in immunostaining. To identify a reliable immunostaining protocol for pigmented melanoma that preserves tissue integrity while enabling clear observation of antigen-antibody binding. Ki67 and the human melanoma black 45 (HMB45) immunostaining was performed on 30 pigmented melanoma specimens using three methods: (1) Unbleached control, (2) Bleached with 5% H₂O₂, (3) Alkaline Phosphatase-3-Amino-9-Ethylcarbazole (AP-AEC). Compared with the unbleached control, the coincidence rates of Ki67 and HMB45 expression in bleached with 5% H
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