Evidence map›Paper›PMID 40825955›Full record

ArticleScientific reports2025

Brucella abortus interferes with the inflammatory response and tissue repair in mice.

M F Silva, D F A Batista, C Eckstein, F B Costa, P P Campos, M A N D Ferreira, M S S Araújo, O A Martins-Filho, R M Tsolis, R L Santos and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. [Analysis of factors affecting fibrosis reversal in patients with metabolic associated steatohepatitis based on magnetic resonance elastography].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

M F SilvaDepartamento de Patologia Geral do Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
D F A BatistaDepartamento de Clínica e Cirurgia Veterinárias da Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
C EcksteinDepartamento de Clínica e Cirurgia Veterinárias da Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
F B CostaDepartamento de Clínica e Cirurgia Veterinárias da Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
P P CamposDepartamento de Patologia Geral do Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
M A N D FerreiraDepartamento de Patologia Geral do Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
M S S AraújoInstituto René Rachou - Fiocruz, Belo Horizonte, MG, Brazil.
O A Martins-FilhoInstituto René Rachou - Fiocruz, Belo Horizonte, MG, Brazil.
R M TsolisDepartment of Medical Microbiology and Immunology, University of California - Davis, Davis, CA, USA.
R L SantosDepartamento de Clínica e Cirurgia Veterinárias da Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Tatiane A PaixãoDepartamento de Patologia Geral do Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. tatipaixao.ufmg@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brucellosis caused by Brucella spp. is considered a debilitating chronic zoonotic disease. B. abortus, which is endemic in many countries, is responsible for chronic bovine and human infections. Interestingly, there are joint and breast implant infections caused by Brucella spp. Although Brucella spp. induce an insidious inflammatory response, little is known about the influence of bacteria on the establishment of early inflammation in vivo, particularly in a synthetic sponge model. B. abortus 2308 was able to survive and replicate in this model, whereas B. abortus Δ virB2 was attenuated, confirming its inability to cause persistent infection. Compared with Δ virB2, B. abortus 2308 is able to modulate the inflammatory response in sponge. We observed that B. abortus 2308 induced a lower influx of inflammatory cells and inflammatory mediators and the formation of fibrovascular tissue at 14 days postimplantation than the control or ΔvirB2-infected mice. Compared with the uninfected sponge, infection by B. abortus in the sponge prolonged the percentage of Mф and M1 macrophages, in addition to increasing the percentage of CD8 + T lymphocytes. B. abortus 2308 can inhibit inflammation in vivo, and the T4SS influences the course of the acute inflammatory process in a synthetic matrix model.

Indexed as

Brucella abortusBrucellosisInflammationAnimalsCD8-Positive T-LymphocytesDisease Models, AnimalFemaleMacrophagesMiceBrucella abortusInflammationInnate immunityType 4 secretion system

Identifiers

PMID40825955
PMCPMC12361577

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.