Evidence map›Paper›PMID 40825947›Full record

ArticleNature communications2025

Molecular basis of ligand binding and receptor activation at the human A

Liudi Zhang, Jesse I Mobbs, Felix M Bennetts, Hariprasad Venugopal, Anh T N Nguyen, Arthur Christopoulos, Daan van der Es, Laura H Heitman, Lauren T May, Alisa Glukhova and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. 4'-Thionucleosides as adenosine AMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  4. Optimized bacterial expression of a synthetic BRIL antibody.Acta crystallographica. Section F, Structural biology communications · 2026
    Article
  5. From empirical screening to lipid trolling: the evolution of extrahelical allosteric modulators of AMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  6. Bitopic AJournal of medicinal chemistry · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Liudi Zhang *Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.
Jesse I Mobbs *Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0001-6979-1427
Felix M BennettsDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0003-2806-608X
Hariprasad VenugopalRamaciotti Centre for Cryo-Electron Microscopy, Monash University, Clayton, VIC, Australia.ORCID http://orcid.org/0000-0001-5230-2973
Anh T N NguyenDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.
Arthur ChristopoulosDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0003-4442-3294
Daan van der EsDivision of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-3662-8177
Laura H HeitmanDivision of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-1381-8464
Lauren T MayDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia. lauren.may@monash.edu.ORCID http://orcid.org/0000-0002-4412-1707
Alisa GlukhovaDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia. glukhova.a@wehi.edu.au.ORCID http://orcid.org/0000-0003-4146-965X
David M ThalDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia. david.thal@monash.edu.ORCID http://orcid.org/0000-0002-0325-2524

Funding

Department of Health | National Health and Medical Research Council (NHMRC) 1138448Department of Health | National Health and Medical Research Council (NHMRC) 1196951National Heart Foundation of Australia (Heart Foundation) 101857
6 · The paper itself

Abstract

Adenosine receptors (ARs: A

Indexed as

Receptor, Adenosine A3AdenosineAdenosine A3 Receptor AgonistsAdenosine A3 Receptor AntagonistsBinding SitesCryoelectron MicroscopyHEK293 CellsHumansHydrogen BondingLigandsModels, MolecularProtein BindingAdenosineAdenosine A3 Receptor AgonistsAdenosine A3 Receptor AntagonistsLigandsReceptor, Adenosine A3

Identifiers

PMID40825947
PMCPMC12361428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.