Observational studyJournal of perinatology : official journal of the California Perinatal Association2025
Antibiotic exposure and infection epidemiology among newborns with congenital diaphragmatic hernia.
Observational study in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo describe infection epidemiology and measure antibiotic utilization among a large cohort of newborns with congenital diaphragmatic hernia (CDH). STUDY
designRetrospective observational study including inborn newborns with CDH at a level IV referral center (free-standing children's hospital with special delivery unit) and two associated level III birth centers who underwent active care and survived to NICU admission, born 1/2013-11/2022 with available disposition.
resultsOf 381 newborns with CDH who were admitted to the NICU, 370 (97.1%) received antibiotics. There were 137 (36.1%) newborns with a positive bacterial culture from any source; 78/381 (20.4%) had a positive culture from blood, urine, or spinal fluid.
conclusionNearly all newborns with CDH at our center received antibiotics during their hospitalization, but the majority did not have a positive bacterial culture result, indicating opportunities exist for antibiotic stewardship among this population.
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