ArticleScientific reports2025
Liposomal ellagic acid enhances the regenerative potential of ADMSC-laden nanofibrous PCL scaffolds in a rat model of spinal cord injury.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Sulforaphane enhances locomotor recovery after spinal cord injury through antioxidant, anti-inflammatory, and JAK/STAT-modulating mechanisms.Current research in neurobiology · 2026Article
- Modulation of p38 MAPK signaling in spinal cord injury by curcumin: targeting inflammation, oxidative stress, and apoptosis.Inflammopharmacology · 2026Review
- The effect of liposomal ellagic acid on the biological properties of dental restorative materials: An in vitro comparative study.Biochemistry and biophysics reports · 2026Article
- Response to "Nanoformulated fingolimod for spinal cord injury: promising anti‑neuroinflammatory effects but unsubstantiated bioavailability claims".Spinal cord · 2026Article
- Targeting the Redox-NF-κB/NLRP3 axis with intranasal liposomal minocycline mitigates aluminum-induced cognitive and structural deficits.Molecular biology reports · 2026Article
- Smart Logistics Model for Supply Chain Management via Brain-Inspired Geometric Deep Networks.Biomimetics (Basel, Switzerland) · 2026Article
- Physical properties comparison of four bioceramic vs. epoxy resin-based root canal sealers: an in vitro study.BMC oral health · 2026Article
- Neuroprotective potential of the natural polyphenol Procyanidin B2 in spinal cord injury: a comprehensive study utilizing machine learning, network pharmacology, andFrontiers in nutrition · 2026Article
- Serum biomarkers for predicting Crohn's disease activity: The role of bilirubin, uric acid, and the C-reactive protein/albumin ratio.PloS one · 2026Article
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Authors and funding
9 authors.
Funding
Abstract
Spinal cord injury (SCI) leads to myelin breakdown and extensive neuronal loss around the injury site due to increased oxidative stress. This study aims to develop a comprehensive platform incorporating scaffolds, therapeutic agents, and stem cells to restore structures and pathways in SCI. Scaffolds were created through the electrospinning of a PCL/functionalized multi-walled carbon nanotube (f-MWCNTs) composite, which was then coated with liposomal ellagic acid (EA@lip) and seeded with adipose-derived mesenchymal stem cells (ADMSCs). The optimal drug concentration was determined by conducting MTT and DPPH assays through three different time points. After assessing the biocompatibility and anti-inflammatory properties of the scaffolds for ADMSCs, the implant was tested in a rat model of dorsal hemisection. The female Wistar rats were divided into six groups (n = 10): Sham, SCI, SCI + PCL/f-MWCNTs (PCs), SCI + scaffolds + EA@lip (PC/N), SCI + scaffolds + ADMSCs (PC/C), and SCI + scaffolds + EA@lip + ADMSCs (PC/N/C). In the second week, biochemical analyses were conducted to evaluate oxidative stress in the animals' blood. Throughout the study, the motor function of the animals was monitored. After six weeks, the rats were subjected to real-time PCR and histological analysis, utilizing Cresyl Violet/Luxol Fast Blue staining and evaluating the expression of the genes COX2, GPX1, MBP, and Slc17a6/7. Liposomal encapsulation efficiency was measured to be 33%. The results revealed that EA@lip had the desired size, zeta potential, and lipid concentration. Transmission electron microscopy revealed that f-MWCNTs were well-aligned along nanofibers. EA@lip dramatically enhanced the hydrophilicity of the scaffolds. The MTT assay, DAPI staining, and FE-SEM images confirmed the successful implantation, proliferation, adhesion, and survival of ADMSCs on the liposome-coated scaffold. Additionally, in vitro oxidative stress tests indicated that this platform exhibited superior antioxidant and anti-inflammatory effects for ADMSCs. Histological assessments revealed that the hybrid platform facilitated the regeneration of myelin and neurons, correlating with improved blood levels of oxidative markers. Furthermore, real-time PCR results demonstrated a decrease in COX2 expression and an increase in GPX1, MBP, and Slc17a6/7 expression due to the platform. The findings suggest that the combination of ADMSCs with EA@lip-coated PCL/f-MWCNT scaffolds hold significant promise for applications in spinal cord regeneration.
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