ReviewMicrosystems & nanoengineering2025
Nucleic acid amplification tests in digital microfluidics: the promise of next-generation point-of-care diagnostics.
Review in Microsystems & nanoengineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- A CRISPR-Cas12a and Quantum-Dot Lateral-Flow Assay for Rapid Species-Level Detection of Trichophyton rubrum.Mycoses · 2026Article
- A fully integrated magnetofluidic system enabled by a wax phase barrier for automated multiplex meat adulteration detection.Microsystems & nanoengineering · 2026Article
- Toothbrush-Driven Handheld Droplet Generator for Digital LAMP and Rapid CFU Assays.Biosensors · 2026Article
- Advances in donor-derived cell-free DNA monitoring for solid organ transplantation.Frontiers in immunology · 2026Review
- Paper-Based Microfluidic Devices: A Powerful Strategy for Rapid Detection.Micromachines · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nucleic acid amplification tests (NAAT) have long been used in laboratory facilities and recently revolutionized the field of molecular diagnostics in point-of-care testing. Digital microfluidics (DMF) has emerged as a promising tool to complete the entire NAAT workflow in a miniaturized format with minimum human intervention. Based on electric fields to manipulate independent reaction droplets, the compact DMF system could perform multiple processes simultaneously and automatically in a programmable fashion. This combination is beginning to establish powerful sample-to-answer platforms in remote or resource-limited settings. Herein, we provide a comprehensive overview of the state-of-the-art DMF technology for point-of-care NAAT. This review focused on key principles of DMF platforms and the latest trends in system integration for automated processes of nucleic acid extraction, amplification, and detection. Also, this article discusses current challenges, including control systems, scalability and throughput, as well as future prospects of DMF-based NAAT strategy for the next generation of point-of-care diagnostics.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.