ArticleScientific reports2025
Leaf litter associated fungi from South Africa to control fungal plant pathogens.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Sulphopreussomerins: Sulfur-Containing Preussomerins Isolated from the Marine-Derived Fungus Pyrenochaetopsis indica.Journal of natural products · 2026Article
- Extremophilic microbial isolates and metagenomic analysis of Greek and Hungarian bauxite residues.Biotechnology reports (Amsterdam, Netherlands) · 2026Article
- Microbial response to long-term spatially stratified phosphorus application in Northeast China.Frontiers in plant science · 2025Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fungal genomes encode a huge biosynthetic potential to produce a wide diversity of chemical structures with valuable biological activities remaining silent or under-expressed with standard laboratory conditions. Fungal natural products provide numerous environmentally friendly properties that make them an attractive alternative to the use of synthetic pesticides for the control management of fungal diseases in plants. The main goal of this study was to explore the potential application of a library of natural products extracts from 232 diverse leaf litter associated fungi from South Africa for the discovery of new bio-fungicides. Fungal strains obtained from the MEDINA Fungal Collection were taxonomically classified following molecular and phylogenetic analyses, revealing a high diversity of fungal strains associated with leaf litter from endemic plants of South Africa. A previously designed library prepared following a specific OSMAC approach was employed in this work to evaluate the antifungal activity on a panel of four relevant fungal phytopathogens, using a recently developed HTS platform. The presence of the epigenetic modifier suberoylanilide hydroxamic acid (SAHA) during fungal fermentations in specific formulation media determined considerable changes in the metabolomic profiles that clearly influenced the diversity and quantity of bioactive metabolites, which also affected the activity hit-rates. As a proof of concept, we describe herein the discovery of the novel molecule libertamide upon the addition of SAHA during the fermentation of the strain Libertasomyces aloeticus CF-168990. Libertamide showed antifungal potential to control Zymoseptoria tritici, the causal agent of septoria leave blotch. As result of the study, we show that leaf litter from South Africa is still an untapped source of new fungal species with large biosynthetic potential to produce promising candidates for the discovery of new natural fungicides.
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