Evidence map›Paper›PMID 40825779›Full record

ArticleNPJ science of food2025

Synbiotic yogurt with nanoparticle entrapped rice straw hemicellulose for immediate probiotic support and prebiotic delivery.

Shaymaa A Ismail, Bahgat Fayed, Hoda S El-Sayed, Hanan A A Taie, Amira A Hassan

Abstract read
In one paragraph

Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Beyond intrinsic resistance: novel insights into the emergence and management of resistance acquired in Candida auris upon antifungal exposure.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shaymaa A IsmailDepartment of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 El Bohouth St., Dokki, 12622, Giza, Egypt.
Bahgat FayedDepartment of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 El Bohouth St., Dokki, 12622, Giza, Egypt. bm.ezzat@nrc.sci.eg.
Hoda S El-SayedDairy Department, Food Industries and Nutrition Research Institute, National Research Centre, 33 El Bohouth St., Dokki, 12622, Giza, Egypt.
Hanan A A TaiePlant Biochemistry Department, Agricultural and Biology Research Institute, National Research Centre, 33 El Bohouth St., Dokki, 12622, Giza, Egypt.
Amira A HassanDepartment of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 El Bohouth St., Dokki, 12622, Giza, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study presents a novel synbiotic yogurt fortified with free and PLGA-entrapped rice straw hemicellulose hydrolyzate (RSHH) to offer immediate probiotic support and sustained prebiotic delivery. RSHH, obtained by enzymatic hydrolysis, yielded 0.5 g/g hemicellulose and was rich in xylooligosaccharides (48.3% reducing sugars), with notable antioxidant activity (45.59 µmol Trolox/mg) and anticancer effects (61.98% reduction in EAC cell viability at 1000 µg/mL). It enhanced the growth of Lactiplantibacillus paraplantarum and Bifidobacterium bifidum more effectively than inulin. Biosafety tests in rats confirmed no adverse effects and improved lipid profiles. RSHH was successfully encapsulated into PLGA nanoparticles (38.77% efficiency, 204.9 nm size, -18.3 mV zeta potential), with spherical morphology, uniform distribution and no aggregation as confirmed by TEM. Yogurt containing both free and entrapped RSHH demonstrated the best performance over 20 days. This dual-delivery system offers a promising solution to enhance probiotic viability and prebiotic stability in functional food applications.

Identifiers

PMID40825779
PMCPMC12361501

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.