Evidence map›Paper›PMID 40825760›Full record

ArticleTranslational psychiatry2025

Multivariate genome-wide association analysis of dyslexia and quantitative reading skill improves gene discovery.

Hayley S Mountford, Else Eising, Pierre Fontanillas, Adam Auton, 23andMe Research Team, Evan K Irving-Pease, Catherine Doust, Timothy C Bates, Nicholas G Martin, Simon E Fisher and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. The Geneticization of Education and Its Bioethical Implications.Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hayley S MountfordSchool of Philosophy, Psychology and Language Sciences, University of Edinburgh, Edinburgh, UK. hayley.mountford@ed.ac.uk.ORCID http://orcid.org/0000-0002-7663-6326
Else EisingLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, Netherlands.ORCID http://orcid.org/0000-0001-9819-1260
Pierre Fontanillas23andMe, Inc., Sunnyvale, CA, USA.ORCID http://orcid.org/0000-0002-8944-4454
Adam Auton23andMe, Inc., Sunnyvale, CA, USA.ORCID http://orcid.org/0000-0002-1630-1225
23andMe Research Team
Evan K Irving-PeaseSection for Molecular Ecology and Evolution, Globe Institute, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-1940-2192
Catherine DoustSchool of Philosophy, Psychology and Language Sciences, University of Edinburgh, Edinburgh, UK.
Timothy C BatesSchool of Philosophy, Psychology and Language Sciences, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-1153-9007
Nicholas G MartinGenetic Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.ORCID http://orcid.org/0000-0003-4069-8020
Simon E FisherLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, Netherlands.ORCID http://orcid.org/0000-0002-3132-1996
Michelle LucianoSchool of Philosophy, Psychology and Language Sciences, University of Edinburgh, Edinburgh, UK. michelle.luciano@ed.ac.uk.ORCID http://orcid.org/0000-0002-7306-3008

Funding

RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/T000813/1
6 · The paper itself

Abstract

The ability to read is an important life skill and a major route to education. Dyslexia, characterized by difficulties with accurate/ fluent word reading, and poor spelling is influenced by genetic variation, with a twin study heritability estimate of 0.4-0.6. Until recently, genomic investigations were limited by modest sample size. We used a multivariate genome-wide association study (GWAS) method, MTAG, to leverage summary statistics from two independent GWAS efforts, boosting power for analyses of dyslexia; the GenLang meta-analysis of word reading (N = 27,180) and the 23andMe, Inc., study of dyslexia (N

Indexed as

DyslexiaGenome-Wide Association StudyReadingChildGenetic LociHumansLongitudinal StudiesMultivariate AnalysisPhenotype

Identifiers

PMID40825760
PMCPMC12361447

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.