Trial reportInternational journal of cardiology2025
Effect of continuous positive airway pressure on ventricular remodeling of patients with combined diabetes mellitus and obstructive sleep apnea: a cross-sectional study and follow-on randomized clinical trial.
Trial report in International journal of cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Obstructive sleep apnea as a modifier of endocrine toxicities associated with immune checkpoint inhibitors in lung cancer.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
backgroundType 2 diabetes mellitus (T2DM) and obstructive sleep apnea (OSA) are independently associated with adverse left (LV) and right (RV) ventricular remodeling. However, little is known about the effect of T2DM and OSA overlap and any additional impact of continuous positive airway pressure (CPAP).
methodsIn this prospective study, 141 participants (Control: 28; T2DM only: 27; OSA only: 29; T2DM + OSA: 57) underwent sleep testing and cardiac magnetic resonance (CMR). Subsequently, 53 with T2DM + OSA were randomized in a 3-month, parallel-arm, trial comparing active and sham CPAP. Measures of interest were LV and RV remodeling indices (mass/volume).
resultsGroups were of similar sex; T2DM + OSA participants were older and had a higher BMI. At baseline, LV remodeling index (g/ml) was higher in T2DM + OSA (0.67 ± 0.12; 0.71 ± 0.10; 0.75 ± 0.13; 0.78 ± 0.16*; respectively, p = 0.01vs. control), whereas RV remodeling index was similar (0.19 ± 0.03; 0.20 ± 0.03; 0.20 ± 0.03; 0.21 ± 0.04; p = 0.33). The difference in LV remodeling index persisted after adjustment for age, sex, and BMI (p < 0.001). The diagnoses of OSA only (b coefficient: 0.08, p = 0.04), and of OSA + T2DM (interaction term; b coefficient: 0.11, p < 0.01) were associated with adverse LV but not RV remodeling. CPAP treatment for 3 months prevented progression of adverse LV remodeling [difference: CPAP: -0.01 (-0.08, 0.08) g/ml; sham: 0.11 (-0.03, 0.17) g/ml; p = 0.03)] but not RV remodeling [difference: CPAP: 0.01 (-0.04, 0.08) g/ml; sham: 0.003 (-0.02, 0.04) g/ml; p = 0.82)].
conclusionThe overlap of T2DM and OSA had an incremental effect on adverse LV remodeling but not RV remodeling. CPAP prevented the progression of LV but not RV remodeling.
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