Evidence map›Paper›PMID 40825505›Full record

ArticleThe Journal of biological chemistry2025

Platelet Jak2 deficiency accelerates atherosclerosis with increased inflammatory response.

Daeun Kim, Yu Zhe Li, Jiaqi Yang, Brian Lin, Meng Yun Wang, Jessie Jia Yu Liu, Jia Qi Adam Bai, Gedaliah Farber, Faisal Abdul Razzaq, Evan Pollock-Tahiri and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Daeun KimToronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
Yu Zhe LiToronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Institute of Medical Science and Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
Jiaqi YangToronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
Brian LinPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Meng Yun WangToronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
Jessie Jia Yu LiuToronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
Jia Qi Adam BaiToronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
Gedaliah FarberToronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
Faisal Abdul RazzaqToronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
Evan Pollock-TahiriToronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
Christopher KhouryDepartment of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St Michael's Hospital, Toronto, Ontario, Canada.
Xi LeiDepartment of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St Michael's Hospital, Toronto, Ontario, Canada.
Guangheng ZhuDepartment of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St Michael's Hospital, Toronto, Ontario, Canada.
Kay-Uwe WagnerDepartment of Oncology, Wayne State University School of Medicine and Tumor Biology Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, USA.
Anastasia A TikhonovaPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
Heyu NiDepartment of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St Michael's Hospital, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Canadian Blood Services Centre for Innovation, Toronto, Ontario, Canada.
Minna WooToronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Department of Immunology, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science and Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada; Division of Endocrinology and Metabolism, Department of Medicine, University Health Network/Sinai Health System, University of Toronto, Toronto, Ontario, Canada. Electronic address: mwoo@uhnres.utoronto.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular disease (CVD) is the leading cause of mortality worldwide, of which atherosclerosis is the major pathology. Chronic inflammation underlies atherosclerosis, and Janus kinase 2 (Jak2) is a critical signaling node that mediates this process. Jak2

Indexed as

AtherosclerosisBlood PlateletsInflammationJanus Kinase 2AnimalsApolipoproteins EHematopoietic Stem CellsMacrophagesMiceMice, KnockoutApolipoproteins EJak2 protein, mouseJanus Kinase 2atherosclerosisbone marrowinflammationJanus kinase (JAK)platelet

Identifiers

PMID40825505
PMCPMC12624798

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.