Evidence map›Paper›PMID 40825477›Full record

ArticleJournal of pharmaceutical sciences2025

Increased longevity of circulating human IgG in an NSG Fc gamma receptor-1 deficient humanized mouse model.

Hannah R Megathlin, Lisa Burzenski, Michael A Brehm, Dale L Greiner, Sathy Balu-Iyer, Leonard D Shultz

Abstract read
In one paragraph

Article in Journal of pharmaceutical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hannah R MegathlinThe Jackson Laboratory, Bar Harbor, Maine 04609, USA; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME 04469, USA.
Lisa BurzenskiThe Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Michael A BrehmProgram in Molecular Medicine, Diabetes Center of Excellence, UMass Chan Medical School, Worcester, MA 01605, USA.
Dale L GreinerProgram in Molecular Medicine, Diabetes Center of Excellence, UMass Chan Medical School, Worcester, MA 01605, USA.
Sathy Balu-IyerDepartment of Pharmaceutical Sciences, University of Buffalo, The State University of New York, Buffalo, NY 14261, USA.
Leonard D ShultzThe Jackson Laboratory, Bar Harbor, Maine 04609, USA; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME 04469, USA. Electronic address: lenny.shultz@jax.org.

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI Paul Robson · 1985 to 2026
$61.9M
Novel Humanized Mouse Models For Engraftment of Tissue-Specific Human Macrophage PopulationR24OD036199 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Michael Allen Brehm, DALE Leslie GREINER · 2024 to 2026
$2.6M
Models to study the synergy between autoimmunity and metabolism in T1DUG3DK142192 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Michael Allen Brehm, George Q Daley · 2025 to 2026
$2.4M
Transdisciplinary Predoctoral Training in Biomedical Science and EngineeringT32GM132006 · NIGMS · UNIVERSITY OF MAINE ORONO · PI GREGORY A. COX, Clarissa A Henry · 2019 to 2026
$2.0M
NCI NIH HHS P30 CA034196NIDDK NIH HHS UG3 DK142192NIGMS NIH HHS T32 GM132006NIH HHS R24 OD036199
6 · The paper itself

Abstract

Monoclonal antibodies (mAbs) are powerful therapeutic tools that are used to treat multiple types of human cancer as well as a diverse set of non-malignant diseases. Humanized NOD.Cg-Prkdc

Indexed as

Immunoglobulin GReceptors, IgGAnimalsAntibodies, MonoclonalFemaleHalf-LifeHumansMiceMice, Inbred NODMice, KnockoutRituximabTrastuzumabAntibodies, MonoclonalImmunoglobulin GReceptors, IgGRituximabTrastuzumabCancerIgg antibody(s)ImmunotherapyMonoclonal antibody(s)Pharmacodynamics

Identifiers

PMID40825477
PMCPMC12687882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.