Evidence map›Paper›PMID 40825473›Full record

ArticleAcademic pediatrics

Developmental Foundations of a Pediatric Mental Health Risk Calculator for Young Children.

Leigha A MacNeill, Yudong Zhang, Gina M Giase, Jillian Lee Wiggins, Elizabeth S Norton, Justin D Smith, Matthew M Davis, Julia G Raven, Roshaye B Poleon, Qiongru Yu and 5 more

Abstract read
In one paragraph

Article in Academic pediatrics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Leigha A MacNeillDepartment of Human Development and Family Science (LA MacNeill), Purdue University, West Lafayette, Ind; Institute for Innovations in Developmental Sciences (LA MacNeill, Y Zhang, GM Giase, ES Norton, MM Davis, NB Allen, and LS Wakschlag), Northwestern University, Chicago, Ill. Electronic address: lamacnei@purdue.edu.
Yudong ZhangInstitute for Innovations in Developmental Sciences (LA MacNeill, Y Zhang, GM Giase, ES Norton, MM Davis, NB Allen, and LS Wakschlag), Northwestern University, Chicago, Ill; Department of Medical Social Sciences (Y Zhang, GM Giase, ES Norton, and LS Wakschlag), Northwestern University Feinberg School of Medicine, Chicago, Ill.
Gina M GiaseInstitute for Innovations in Developmental Sciences (LA MacNeill, Y Zhang, GM Giase, ES Norton, MM Davis, NB Allen, and LS Wakschlag), Northwestern University, Chicago, Ill; Department of Medical Social Sciences (Y Zhang, GM Giase, ES Norton, and LS Wakschlag), Northwestern University Feinberg School of Medicine, Chicago, Ill.
Jillian Lee WigginsDepartment of Psychology (JL Wiggins), San Diego State University, San Diego, Calif; Joint Doctoral Program in Clinical Psychology (JL Wiggins and Q Yu), San Diego State University, San Diego, Calif.
Elizabeth S NortonInstitute for Innovations in Developmental Sciences (LA MacNeill, Y Zhang, GM Giase, ES Norton, MM Davis, NB Allen, and LS Wakschlag), Northwestern University, Chicago, Ill; Department of Medical Social Sciences (Y Zhang, GM Giase, ES Norton, and LS Wakschlag), Northwestern University Feinberg School of Medicine, Chicago, Ill; Department of Communication Sciences and Disorders (ES Norton), Northwestern University, Evanston, Ill.
Justin D SmithDepartment of Population Health Sciences (JD Smith), Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, Utah.
Matthew M DavisInstitute for Innovations in Developmental Sciences (LA MacNeill, Y Zhang, GM Giase, ES Norton, MM Davis, NB Allen, and LS Wakschlag), Northwestern University, Chicago, Ill; Nemours Children's Health (MM Davis), Wilmington, Del.
Julia G RavenDepartment of Human Services (JG Raven), Clinical and School Psychology, University of Virginia, Charlottesville, Va.
Roshaye B PoleonDepartment of Human Development and Family Science (RB Poleon), University of Georgia, Athens, Ga.
Qiongru YuJoint Doctoral Program in Clinical Psychology (JL Wiggins and Q Yu), San Diego State University, San Diego, Calif.
Christopher D SmyserMallinckrodt Institute of Radiology (CD Smyser), Washington University School of Medicine, St Louis, Mo; Department of Pediatrics (CD Smyser and CE Rogers), Washington University School of Medicine, St Louis, Mo; Department of Neurology (CD Smyser), Washington University School of Medicine, St Louis, Mo.
Cynthia E RogersDepartment of Pediatrics (CD Smyser and CE Rogers), Washington University School of Medicine, St Louis, Mo; Department of Psychiatry (CE Rogers and JL Luby), Washington University School of Medicine, St Louis, Mo.
Joan L LubyDepartment of Psychiatry (CE Rogers and JL Luby), Washington University School of Medicine, St Louis, Mo.
Norrina B AllenInstitute for Innovations in Developmental Sciences (LA MacNeill, Y Zhang, GM Giase, ES Norton, MM Davis, NB Allen, and LS Wakschlag), Northwestern University, Chicago, Ill; Department of Preventive Medicine (NB Allen), Northwestern University Feinberg School of Medicine, Chicago, Ill.
Lauren S WakschlagInstitute for Innovations in Developmental Sciences (LA MacNeill, Y Zhang, GM Giase, ES Norton, MM Davis, NB Allen, and LS Wakschlag), Northwestern University, Chicago, Ill; Department of Medical Social Sciences (Y Zhang, GM Giase, ES Norton, and LS Wakschlag), Northwestern University Feinberg School of Medicine, Chicago, Ill.

Funding

Early Life Adversity, Biological Embedding, and Risk for Developmental Precursors of Mental DisordersR01MH113883 · NIMH · WASHINGTON UNIVERSITY · PI JOAN L. LUBY, Christopher Daniel Smyser · 2018 to 2026
$20.6M
Optimizing prediction of preschool psychopathology from brain: behavior markers of emotion dysregulation from birth: A computational, developmental cognitive neuroscience approachR01MH121877 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LUBY, JOAN L., ROGERS, CYNTHIA ELISE · 2020 to 2024
$8.2M
Generating an Earlier Science of When to Worry: A Neurodevelopmental, Transactional Approach to Characterizing Irritability Patterns Beginning in InfancyR01MH107652 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WAKSCHLAG, LAUREN S · 2016 to 2021
$4.0M
NIMH NIH HHS R01 MH107652NIMH NIH HHS R01 MH113883NIMH NIH HHS R01 MH121877
6 · The paper itself

Abstract

objectiveTo advance the clinical utility of an emerging risk calculator for identifying when to worry and when to act when young children show signs of mental health concerns in pediatric care, we 1) replicate an early childhood mental health risk algorithm (DECIDE); 2) determine the preliminary predictive utility of additional child and parenting assets, advancing a strengths-based framework to reduce the likelihood of biased identification.

methodsData were from 2 independent studies: the national Future of Families and Child Wellbeing Study (FFCWS; N = 2763) and the regional Mental Health, Earlier Synthetic Cohort study (MHESC; N = 323). Predictors were assessed in toddlerhood/early preschool age. Internalizing/externalizing problems were measured in older preschoolers, serving as outcomes. Epidemiologic risk prediction methods were applied to 1) replicate the DECIDE risk algorithm domains comprised of demographics, child irritability, and adverse childhood experiences; 2) examine the added predictive utility of child and parenting assets. Predictive utility was based on area under the curve (AUC) and/or the integrated discrimination improvement (IDI).

resultsThe DECIDE algorithm was replicated in FFCWS and MHESC (AUC = 0.70 for both studies; IDI = 0.07 in FFCWS and 0.06 in MHESC). IDIs indicated predictive utility for child assets beyond the existing DECIDE algorithm in both studies, and for parenting assets in FFCWS.

conclusionsRobust validation of predictive algorithms is critical for assessing generalizability. Reducing bias in early mental health risk algorithms via a strengths-based approach is key to equitable decision-making. This work lays the foundation for implementation of early mental health decision tools in routine care of young children.

Indexed as

AlgorithmsMental DisordersMental HealthAdverse Childhood ExperiencesChild, PreschoolCohort StudiesFemaleHumansInfantMaleParentingRisk Assessmentclinical decision-makingdevelopmentally-informedearly childhood mental healthrisk calculator

Identifiers

PMID40825473
PMCPMC12677145

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.