Evidence map›Paper›PMID 40825372›Full record

ArticleMagnetic resonance in chemistry : MRC2025

HEteronuclear Referencing for METRologic Isotope Calibration (HERMETRIC).

Bernd W K Diehl, Jakob V Waldthausen, Yulia Monakhova

Abstract read
In one paragraph

Article in Magnetic resonance in chemistry : MRC, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bernd W K DiehlSpectral Service AG, Cologne, Germany.
Jakob V WaldthausenSpectral Service AG, Cologne, Germany.ORCID https://orcid.org/0009-0003-6218-3439
Yulia MonakhovaSpectral Service AG, Cologne, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This work presents the concept of heteronuclear referencing for metrologic isotope calibration (HERMETRIC) as an innovative approach to quantitative NMR (qNMR) spectroscopy. The aim is to establish a metrologically based fundamental understanding that goes beyond traditional homonuclear NMR methods. In comparison to established quantitative methods-such as weighing, titration, chromatography, and complexometry-it is demonstrated that qNMR, as a primary method, can determine absolute amounts of substance directly without external calibration. At the same time, heteronuclear quantification opens new perspectives by enabling the direct traceability of all active nuclei to a universal qNMR primary standard. The concepts are intended to encourage the further establishment of qNMR as a powerful instrument in analytical chemistry and its incorporation into pharmacopoeias and other official standard protocols.

Indexed as

analytical principlescomplexometryheteronuclear quantitative NMR spectroscopyisotopic analysismethods comparisontitrationweighing

Identifiers

PMID40825372
PMCPMC12500356

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.