Evidence map›Paper›PMID 40825128›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Inbreeding reduces fitness in spatially structured populations of a threatened rattlesnake.

Meaghan I Clark, Eric T Hileman, Jennifer A Moore, Lisa J Faust, Randall E Junge, Brendan N Reid, Danielle R Bradke, Gideon S Bradburd, Sarah W Fitzpatrick

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Inbreeding reduces fitness in spatially structured populations of a threatened rattlesnake.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Meaghan I ClarkDepartment of Integrative Biology, Michigan State University, East Lansing, MI 48824.ORCID 0000-0003-3297-8372
Eric T HilemanWildlife and Fisheries Resources Program, School of Natural Resources and the Environment, West Virginia University, Morgantown, WV 26506.ORCID 0000-0002-7044-370X
Jennifer A MooreBiology Department, Grand Valley State University, Allendale, MI 49401.ORCID 0000-0001-8143-0392
Lisa J FaustAlexander Center for Applied Population Biology, Lincoln Park Zoo, Chicago, IL 60614.ORCID 0000-0001-6175-8999
Randall E JungeDepartment of Conservation Medicine, Columbus Zoo and Aquarium, Powell, OH 43065.ORCID 0000-0002-9989-4053
Brendan N ReidDepartment of Integrative Biology, Michigan State University, East Lansing, MI 48824.
Danielle R BradkeWarnell School of Forestry and Natural Resources, University of Georgia, Athens, GA 30602.
Gideon S BradburdDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109.
Sarah W FitzpatrickDepartment of Integrative Biology, Michigan State University, East Lansing, MI 48824.ORCID 0000-0002-5610-9449

Funding

Incorporating geography into statistical methods for analysis of population genomic DNAR35GM137919 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Gideon Bradburd · 2020 to 2026
$2.3M
Great Lakes Fish and Wildlife Restoration Act F19AP00663HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM137919HSRD VA HIR 10-001NIGMS NIH HHS R35 GM137919NSF | BIO | Division of Environmental Biology (DEB) 2016569
6 · The paper itself

Abstract

Small and fragmented populations are at high risk of local extinction, in part because of elevated inbreeding and subsequent inbreeding depression. A major conservation priority is to identify the mechanisms and extent of inbreeding depression in small populations. The eastern massasauga (

Indexed as

CrotalusEndangered SpeciesGenetic FitnessInbreedingInbreeding DepressionAnimalsConservation of Natural ResourcesFemaleMaleMichiganinbreedinginbreeding depressionpedigreespopulation structure

Identifiers

PMID40825128
PMCPMC12403008

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.