Evidence map›Paper›PMID 40825123›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Elucidating the role of

Jong-Duk Park, Seoung Rak Lee, Catherine Dhennezel, Noel Taylor, Andrea Dame, Motohiko Kadoki, Gleb Pishchany, Daniel B Graham, Ramnik J Xavier, Mohammad R Seyedsayamdost

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Leveraging antibiotic hormesis for cryptic natural product discovery.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jong-Duk Park *Department of Chemistry, Princeton University, Princeton, NJ 08544.
Seoung Rak Lee *Department of Chemistry, Princeton University, Princeton, NJ 08544.ORCID 0009-0006-8696-2949
Catherine DhennezelBroad Institute of MIT and Harvard, Cambridge, MA 02142.
Noel TaylorBroad Institute of MIT and Harvard, Cambridge, MA 02142.ORCID 0009-0007-8120-9525
Andrea DameBroad Institute of MIT and Harvard, Cambridge, MA 02142.
Motohiko KadokiBroad Institute of MIT and Harvard, Cambridge, MA 02142.ORCID 0000-0002-0124-7406
Gleb PishchanyBroad Institute of MIT and Harvard, Cambridge, MA 02142.
Daniel B GrahamBroad Institute of MIT and Harvard, Cambridge, MA 02142.ORCID 0000-0002-8403-8115
Ramnik J XavierBroad Institute of MIT and Harvard, Cambridge, MA 02142.ORCID 0000-0002-5630-5167
Mohammad R SeyedsayamdostDepartment of Chemistry, Princeton University, Princeton, NJ 08544.ORCID 0000-0003-2707-4854

Funding

Identification and Characterization of Microbial Metabolites in ImmunityR01AI172147 · NIAID · BROAD INSTITUTE, INC. · PI Daniel Bartholomew Graham, Ramnik J Xavier · 2022 to 2026
$3.9M
Leona M. and Harry B. Helmsley Charitable Trust (Helmsley Charitable Trust) 2023A004123NIAID NIH HHS R01 AI172147
6 · The paper itself

Abstract

The gut microbiota plays a pivotal role in maintaining human health with dysbiosis linked to a variety of diseases. Metagenome sequencing and robust statistical analysis have linked specific strains, including the gut bacterium

Indexed as

CampylobacterGastrointestinal MicrobiomeIndolesInflammationAnimalsCytokinesHumansInflammatory Bowel DiseasesMacrophagesMiceMice, Inbred C57BLCytokinesindoleIndolescytokinesinflammatory bowel diseasemicrobiomenatural products

Identifiers

PMID40825123
PMCPMC12403104

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.