Evidence map›Paper›PMID 40824714›Full record

ArticleAntimicrobial agents and chemotherapy2025

A screen to identify antifungal antagonists reveals a variety of pharmacotherapies that induce echinocandin tolerance in

Parker Reitler, Christian A DeJarnette, Ravinder Kumar, Katie M Tucker, Tracy L Peters, Nathaniel R Twarog, Anang A Shelat, Glen E Palmer

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Parker ReitlerDepartment of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.
Christian A DeJarnetteDepartment of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.ORCID 0000-0002-9733-9152
Ravinder KumarDepartment of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.
Katie M TuckerDepartment of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.
Tracy L PetersDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Nathaniel R TwarogDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Anang A ShelatDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Glen E PalmerDepartment of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.ORCID 0000-0003-4083-3130

Funding

Antifungal antagonism as a cause of treatment failure for invasive mycosesR01AI152067 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI PALMER, GLEN · 2021 to 2025
$3.1M
National Institute of Allergy and Infectious Diseases R01AI152067NIAID NIH HHS R01 AI152067
6 · The paper itself

Abstract

Through screening a comprehensive collection of drugs approved for human use, we identified over 20 that oppose the antifungal activity of the echinocandins upon the infectious yeast,

Indexed as

Antifungal AgentsCandida albicansEchinocandinsDrug Resistance, FungalFungal ProteinsGene Expression Regulation, FungalHumansMicrobial Sensitivity TestsSignal TransductionAntifungal AgentsEchinocandinsFungal Proteinsantifungal resistanceCandida albicansechinocandin

Identifiers

PMID40824714
PMCPMC12486808

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.