SynthesisJournal of materials science. Materials in medicine2025
The role of magnesium hydrogels in bone regeneration: a systematic review and meta-analysis.
Synthesis in Journal of materials science. Materials in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- In vitro investigation of osteogenic differentiation and bone regeneration potential of magnesium oxide nanoparticles incorporated into bacterial cellulose/silk fibroin scaffolds.Scientific reports · 2026Article
- A Review on Recent Progress and Clinical Translation of Self-Assembled Hydrogels in Diabetic Wound Repair.International journal of nanomedicine · 2026Review
- Tri-Functional MgTA@MnOInternational journal of nanomedicine · 2026Article
- Size-Optimized LDH Nanoplatelet-Reinforced GelMA Hydrogels Orchestrate Osteoimmunomodulation for Critical-Sized Bone Defect Repair.International journal of nanomedicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Magnesium, an essential element in human physiology, is predominantly located in bone tissue. Since the early 20th century, magnesium-based biomaterials have demonstrated osteoinductive and angiogenic potential, positioning them as promising candidates for bone regeneration strategies. Hydrogels, composed of crosslinked hydrophilic polymers, provide a three-dimensional microenvironment mimicking the extracellular matrix (ECM), thereby supporting cell adhesion, nutrient diffusion, and controlled release of bioactive ions such as Mg²⁺. Recent advances in material science have enabled the design of multifunctional magnesium-loaded hydrogels that synergistically combine mechanical stability, immunomodulation, and spatiotemporal Mg²⁺ release to address critical-sized bone defects. This review systematically examines hydrogel classifications and elucidates magnesium-mediated biological signaling pathways that drive bone repair. A meta-analysis of 10 studies retrieved from PubMed, Web of Science, Scopus, and Embase was performed to assess the efficacy of magnesium-containing hydrogels in bone repair. The findings demonstrate that magnesium significantly enhances bone repair processes, underscoring its potential as a therapeutic agent for bone defect treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.