Evidence map›Paper›PMID 40824561›Full record

Observational studyInternational ophthalmology2025

Ganglion cell function loss in extensive macular atrophy with pseudodrusen.

Sung Eun Song Watanabe, Andressa Zanini Fantato Quercia, Glaycielli Pereira Santos Mandaro de Assis, Milena Leal Borges, Paula Yuri Sacai

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sung Eun Song WatanabeG6 Electrophysiology Laboratory, Rua Doutor Diogo de Faria, São Paulo, São Paulo, 1202, Brazil. sungwatanabe@yahoo.com.br.
Andressa Zanini Fantato QuerciaG6 Electrophysiology Laboratory, Rua Doutor Diogo de Faria, São Paulo, São Paulo, 1202, Brazil.
Glaycielli Pereira Santos Mandaro de AssisG6 Electrophysiology Laboratory, Rua Doutor Diogo de Faria, São Paulo, São Paulo, 1202, Brazil.
Milena Leal BorgesG6 Electrophysiology Laboratory, Rua Doutor Diogo de Faria, São Paulo, São Paulo, 1202, Brazil.
Paula Yuri SacaiG6 Electrophysiology Laboratory, Rua Doutor Diogo de Faria, São Paulo, São Paulo, 1202, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study allows the functional evaluation of all retinal layers in individuals with extensive macular atrophy with pseudodrusen. The findings may contribute to the elucidation of the disease's pathophysiology. The purpose of this retrospective observational study is to determine ganglion cell function in individuals with extensive macular atrophy with pseudodrusen by measuring the photopic negative response.

methodsRetrospective observational study included patients with EMAP who were seen at a visual electrophysiology laboratory.

resultsFifty-four patients with extensive macular atrophy with pseudodrusen were evaluated, with 39% having normal visual acuity, 41% bilateral visual impairment, and 20% unilateral impairment; all had characteristic retinal findings, including retinal pigment epithelium atrophy and pseudodrusen. Full-field electroretinogram responses showed significantly reduced amplitudes in all groups compared to reference ranges, with no significant differences between better and worse eyes. The photopic negative response amplitudes (BT and PT) were reduced in all patients, indicating functional loss of retinal ganglion cells, while photoreceptor responses were less affected.

conclusionThis study highlights the importance of assessing retinal ganglion cell function through the Photopic Negative Response as a potential functional biomarker and suggests that extensive macular atrophy with pseudodrusen may involve broader retinal and systemic dysfunction beyond photoreceptor impairment.

Indexed as

Macula LuteaRetinal DrusenRetinal Ganglion CellsVisual AcuityAdultAgedAged, 80 and overAtrophyElectroretinographyFemaleHumansMaleMiddle AgedRetrospective StudiesTomography, Optical CoherenceExtensive macular atrophy with pseudodrusenPhotopic negative responseRetinal degenerationRetinopathy

Identifiers

PMID40824561

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.