ArticleExperimental brain research2025
A novel finding on the sex-dependent role of BDNF and GSK-3beta in the medial prefrontal cortex in pain threshold changes in a rat model of fear conditioning with respect to the effect of extinction and the time period after conditioning.
Article in Experimental brain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Investigating the effects of chlorogenic acid on novel object recognition memory impairment, hyperlocomotion, and prefrontal BDNF expression in a sub-chronic ketamine-induced schizophrenia-like rat model.IBRO neuroscience reports · 2026Article
- A novel finding on sex-dependent diverse behavioral responses to the anticipation of a threat in a rat model of fear conditioning with the involvement of brain-derived neurotrophic factor (BDNF) in the prefrontal cortex.Learning & behavior · 2026Article
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7 authors.
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Abstract
Evidence has shown a wide range of changes in pain perception in posttraumatic stress disorder (PTSD). The present study aimed to explore changes in thermal pain threshold in both sexes of rats exposed to electrical footshocks in different periods after fear conditioning. Fear conditioning (PTSD-like model) was induced by three footshocks (0.8 mA, 3 s) paired with sounds (75 dB, 3 s). Extinction was performed using twenty sounds (75 dB, 3 s) with no footshocks, 1 h after footshocks. Freezing and pain threshold were measured 2 h, 2 days, 7 days, or 30 days after PTSD or extinction (there was not any recall session). The results showed freezing behavior showed a downward trend over time in males, while an upward trend over time in females. Extinction slightly decreased freezing behavior in males, while significantly decreased it in females. Pain threshold was increased in male PTSD rats, while after 30days, there was no change in pain perception. In females, pain threshold was restored in both PTSD-7d and - 30d groups. Extinction decreased pain threshold in males, with stronger effect in females. BDNF was decreased and GSK-3beta was increased in male PTSD rats, except PTSD-30d only for BDNF. In females, BDNF level was restored in both PTSD-7d and - 30d, and also, increased in PTSD-2d group, while GSK-3beta was increased. In conclusion, significant sex differences were observed in freezing behavior, pain threshold, and BDNF. Notably, it seems that GSK-3beta may be involved in freezing and pain perception changes only in females exposed to extinction session.
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