Evidence map›Paper›PMID 40824506›Full record

ArticleInternational journal of computer assisted radiology and surgery2026

Interactive AI annotation of medical images in a virtual reality environment.

Lotta Orsmaa, Mikko Saukkoriipi, Jari Kangas, Nastaran Rasouli, Jorma Järnstedt, Helena Mehtonen, Jaakko Sahlsten, Joel Jaskari, Kimmo Kaski, Roope Raisamo

Abstract read
In one paragraph

Article in International journal of computer assisted radiology and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lotta OrsmaaFaculty of Information Technology and Communication Sciences, Tampere University, Kalevantie 4, 33014, Tampere, Finland. lotta.orsmaa@tuni.fi.ORCID http://orcid.org/0009-0005-1738-4965
Mikko SaukkoriipiDepartment of Computer Science, Aalto University School of Science, Otakaari 1B, 00076, Espoo, Finland.ORCID http://orcid.org/0000-0003-3735-5860
Jari KangasFaculty of Information Technology and Communication Sciences, Tampere University, Kalevantie 4, 33014, Tampere, Finland.ORCID http://orcid.org/0000-0003-1970-1862
Nastaran RasouliFaculty of Information Technology and Communication Sciences, Tampere University, Kalevantie 4, 33014, Tampere, Finland.ORCID http://orcid.org/0009-0008-5015-3984
Jorma JärnstedtDepartment of Radiology, Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Elämänaukio 2, 33520, Tampere, Finland.ORCID http://orcid.org/0000-0003-1503-3078
Helena MehtonenDepartment of Radiology, Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Elämänaukio 2, 33520, Tampere, Finland.
Jaakko SahlstenDepartment of Computer Science, Aalto University School of Science, Otakaari 1B, 00076, Espoo, Finland.ORCID http://orcid.org/0000-0002-7364-6502
Joel JaskariDepartment of Computer Science, Aalto University School of Science, Otakaari 1B, 00076, Espoo, Finland.ORCID http://orcid.org/0000-0002-6154-2378
Kimmo KaskiDepartment of Computer Science, Aalto University School of Science, Otakaari 1B, 00076, Espoo, Finland.ORCID http://orcid.org/0000-0002-3805-9687
Roope RaisamoFaculty of Information Technology and Communication Sciences, Tampere University, Kalevantie 4, 33014, Tampere, Finland.ORCID http://orcid.org/0000-0003-3276-7866

Funding

Business Finland 80/31/2023Research Council of Finland 345448
6 · The paper itself

Abstract

purposeArtificial intelligence (AI) achieves high-quality annotations of radiological images, yet often lacks the robustness required in clinical practice. Interactive annotation starts with an AI-generated delineation, allowing radiologists to refine it with feedback, potentially improving precision and reliability. These techniques have been explored in two-dimensional desktop environments, but are not validated by radiologists or integrated with immersive visualization technologies. We used a Virtual Reality (VR) system to determine whether (1) the annotation quality improves when radiologists can edit the AI annotation and (2) whether the extra work done by editing is worthwhile.

methodsWe evaluated the clinical feasibility of an interactive VR approach to annotate mandibular and mental foramina on segmented 3D mandibular models. Three experienced dentomaxillofacial radiologists reviewed AI-generated annotations and, when needed, refined them at the voxel level in 3D space through click-based interactions until clinical standards were met.

resultsOur results indicate that integrating expert feedback within an immersive VR environment enhances annotation accuracy, improves clinical usability, and offers valuable insights for developing medical image analysis systems incorporating radiologist input.

conclusionThis study is the first to compare the quality of original and interactive AI annotation and to use radiologists' opinions as the measure. More research is needed for generalization.

Indexed as

Artificial IntelligenceVirtual RealityFeasibility StudiesHumansImaging, Three-DimensionalMandibleReproducibility of ResultsTomography, X-Ray ComputedUser-Computer InterfaceAI annotationInteractive AIMedical imagingVirtual reality

Identifiers

PMID40824506
PMCPMC12929304

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.