ArticleCell biochemistry and biophysics2025
Inducing Oxidative Stress-Driven Senescent Phenotype in Induced Pluripotent Stem Cell Derived Cardiomyocytes.
Article in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Disruption of ATP Synthase Spatiotemporal Organization, CaAging cell · 2026Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular diseases (CVDs) pose a significant health challenge, particularly among aging populations. Age-related cellular transformations, such as apoptosis, fibrosis, and senescence, contribute to CVDs, necessitating a deeper understanding of cellular aging mechanisms. While animal models offer insights, their translational relevance remains limited, underscoring the need for human-based models. Induced pluripotent stem cells (iPSCs) present a promising avenue for aged tissue modeling, that enable personalized and ethical approaches. By differentiating iPSCs into induced cardiomyocytes (iCMs) and aging them, researchers can simulate age-related cardiac conditions. We assessed in vitro aging conditions by inducing oxidative stress, a key driver of aging, as it is crucial for replicating age-related pathological changes in aged tissue models. We exposed the iCMs to varying concentrations and exposure durations of hydrogen peroxide treatments. Through analyzing cellular aging markers such as senescence, p21 expression, and cellular waste accumulation, we compared the different treatments to determine the most time efficient approach. Our results showed that 7-day 200 µM hydrogen peroxide treatment leads to a significant increase in senescence, p21 and p16INK4A expression, and cellular waste accumulation, without inducing apoptosis. These cells can be used for developing iPSC-based aged tissue models towards advancing our understanding and treatment of age-related CVDs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.