Evidence map›Paper›PMID 40824431›Full record

ReviewClinical reviews in allergy & immunology2025

Malignancy in Idiopathic Inflammatory Myopathies: Recent Insights.

Hongzheng Wu, Xiaomeng Li, Honglin Xu, Zhan Li, Futai Feng, Jingdi Zhang, Zhixin Xu, Haoxi Ni, Ye Guo, Yongzhe Li

Abstract readReview
In one paragraph

Review in Clinical reviews in allergy & immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hongzheng Wu *Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 1Shuaifuyuan, Dongcheng District, Beijing, China, 100730.
Xiaomeng Li *Department of Clinical Laboratory, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, China, 100044.
Honglin XuDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 1Shuaifuyuan, Dongcheng District, Beijing, China, 100730.
Zhan LiDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 1Shuaifuyuan, Dongcheng District, Beijing, China, 100730.
Futai FengDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 1Shuaifuyuan, Dongcheng District, Beijing, China, 100730.
Jingdi ZhangDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 1Shuaifuyuan, Dongcheng District, Beijing, China, 100730.
Zhixin XuDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 1Shuaifuyuan, Dongcheng District, Beijing, China, 100730.
Haoxi NiDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 1Shuaifuyuan, Dongcheng District, Beijing, China, 100730.
Ye GuoDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 1Shuaifuyuan, Dongcheng District, Beijing, China, 100730. 4227582@163.com.
Yongzhe LiDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 1Shuaifuyuan, Dongcheng District, Beijing, China, 100730. yongzhelipumch@126.com.

Funding

Peking University People's Hospital Scientific Research Development Funds RDJP2024-25the National High Level Hospital Clinical Research Funding 2022-PUMCH-B-124the National Natural Science Foundation of China 82402698
6 · The paper itself

Abstract

Idiopathic inflammatory myopathies (IIMs) are a group of rare autoimmune diseases in which several subtypes, primarily dermatomyositis (DM), are associated with a high risk of malignancy. Although the relationship between the pathogenesis of IIMs and co-occurring malignancy is poorly understood, there is a growing evidence base for specific risk factors which are associated with cancer-associated myositis (CAM), including myositis-specific or myositis-associated autoantibodies (MSAs/MAAs). In addition, given that patients with different subtypes of IIMs, as classified according to clinical manifestations or serum autoantibody measurement, exhibit heterogeneity in tumorigenesis, further research is urgently needed to explore the pathogenesis of CAM, in order to develop novel biomarkers and therapeutic alternatives for patients. This review discusses the risk and protective factors for CAM using the available evidence, thereby offering fresh insights into its pathogenesis, screening, and management strategies and highlighting possible future breakthroughs and obstacles in this field.

Indexed as

MyositisNeoplasmsAnimalsAutoantibodiesBiomarkersDermatomyositisDisease SusceptibilityHumansRisk FactorsAutoantibodiesBiomarkersCancerCancer-associated myositisIdiopathic inflammatory myopathies

Identifiers

PMID40824431
PMCPMC12361316

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.