ArticleCurrent microbiology2025
Characterization and Genome Comparison of Bacteriophage KKU62-1 Infecting Hypervirulent Streptococcus agalactiae ST283.
Article in Current microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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Authors and funding
8 authors.
Funding
Abstract
Streptococcus agalactiae is a multi-host pathogen affecting humans, cattle and aquatic animals. Phage therapy, recognized for its specificity and rapid bacterial killing, offers an alternative. This study aimed to characterize phage KKU62-1, which showed lytic activities against S. agalactiae. The phage with a hexagonal head and a long non-contractile tail was classified as a member of the Siphoviridae family. It exhibited stability at a wide pH (5-10) and thermal (4-40 °C) ranges. It demonstrated a short latent period (15 min) and a rise period of 75 min. Interestingly, KKU62-1 showed high specificity against a hypervirulent strain, S. agalactiae sequence type (ST)283 (78.9%). Its genome sequence was most similar to phage vB_Sags-UPM1 sharing 99.93% identity. Interestingly, a small distinct region with a low degree (41.84%) of identity in YopX family gene of KKU62-1 and vB_Sags-UPM1 was detected. The regions in KKU62-1 covered a 141-bp (Var-141), while in vB_Sags-UPM1 expanded a 138-bp (Var-138). These sequence variants were also found in some prophages of S. agalactiae, especially of the ST283. Additionally, this study was the first to explore the diversity (4 distinct types) of the YopX family gene among S. agalactiae and its phages. In conclusion, KKU62-1 and vB_Sags-UPM1 were almost identical phage, but a small recombination in the YopX family gene has made them apart.
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