Observational studyJapanese journal of ophthalmology2026
Clinical characteristics and risk factors for corneal guttae in Japanese cataract patients.
Observational study in Japanese journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- FECD-like histopathological features of descemet's membrane in bullous keratopathy associated with primary angle closure.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Bullous keratopathy associated with a shallow anterior chamber: An anatomical risk phenotype for corneal endothelial decompensation.PloS one · 2026Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo identify clinical characteristics and risk factors associated with corneal guttae in Japanese patients undergoing cataract surgery and to examine the relationship between guttae severity and anterior segment parameters. STUDY
designThis retrospective observational study analyzed 410 eyes from 410 patients who underwent cataract surgery between April 2021 and March 2023.
methodsCorneal guttae were evaluated using specular microscopy and graded according to the modified Reykjavik Eye Study classification (Grades 0-4). Demographics, corneal endothelial characteristics, and ocular biometric parameters were assessed. Univariate and multivariate logistic regression analyses were performed to identify risk factors for corneal guttae.
resultsCorneal guttae were present in 23.2% of patients (Grade 1: 17.1%, Grade 2: 4.9%, Grade 3: 0.7%, Grade 4: 0.5%). Multivariate analysis identified female gender (OR=1.81, 95% CI: 1.04-3.14, p=0.036), shallower anterior chamber depth (OR=0.47, 95% CI: 0.23-0.98, p=0.043), corneal endothelial cell density (per 100 cells/mm
conclusionsFemale gender, shallow anterior chamber, low endothelial cell density, and hyperopic refractive error are independently associated with corneal guttae in Japanese cataract patients. Progressive changes across severity grades suggest that anatomical factors contribute to endothelial vulnerability. These findings enhance the understanding of guttae pathophysiology and improve preoperative risk assessment.
Indexed as
Identifiers
40824423What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.