Evidence map›Paper›PMID 40824401›Full record

ArticleThe Journal of cell biology2025

FOMO no more: NOMO and calmin extend mechanobiology to the ER.

Julie Heffler, Jan Lammerding

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Julie HefflerWeill Institute for Cell and Molecular Biology, Meinig School of Biomedical Engineering, Cornell University , Ithaca, NY, USA.ORCID 0000-0002-7694-0168
Jan LammerdingWeill Institute for Cell and Molecular Biology, Meinig School of Biomedical Engineering, Cornell University , Ithaca, NY, USA.ORCID 0000-0003-4335-8611

Funding

Nuclear mechanics and mechanotransduction in muscular laminopathiesR01HL082792 · NHLBI · CORNELL UNIVERSITY · PI LAMMERDING, JAN · 2007 to 2023
$4.8M
Defining nuclear mechanisms for ultrarapid mechanically induced gene expressionR01AR084664 · NIAMS · CORNELL UNIVERSITY · PI JOHN T LIS, Jan Lammerding · 2024 to 2026
$1.8M
Nuclear mechanobiology in confined migration (equipment supplement 2026)R35GM153257 · NIGMS · CORNELL UNIVERSITY · PI Jan Lammerding · 2024 to 2026
$1.3M
Fleming Postdoctoral FellowshipLeducq Foundation 20CVD01Leducq Foundation 24CVD03National Science Foundation URoL2022048NHLBI NIH HHS R01 HL082792NIAMS NIH HHS R01 AR084664NIGMS NIH HHS R35 GM153257NIH HHS R01 AR084664NIH HHS R01 HL082792NIH HHS R35 GM153257Volkswagen Foundation A130142
6 · The paper itself

Abstract

Research on cellular mechanotransduction has primarily focused on the cell surface and the cytoskeleton. In this issue, Naughton et al. (https://doi.org/10.1083/jcb.202505010) identify NOMO, an endoplasmic reticulum (ER)-resident protein, as a force-bearing element with crucial roles in muscle differentiation and function. In a complementary study, Merta et al. (https://doi.org/10.1016/j.celrep.2025.115502) demonstrate that calmin physically tethers ER tubules to actin filaments at focal adhesions, modulating their function.

Indexed as

Endoplasmic ReticulumMechanotransduction, CellularActin CytoskeletonAnimalsFocal AdhesionsHumans

Identifiers

PMID40824401
PMCPMC13047711

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.