ArticleFuture science OA2025
Using IgY for diagnosis of respiratory infections: practical application in COVID-19.
Article in Future science OA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
aimThe COVID-19 pandemic underscores the need for expanded diagnostic tools to combat respiratory pathogens with pandemic potential, particularly in developing countries. This study aimed to create a Dot Blotting test utilizing IgY antibodies for acute respiratory infection diagnosis, with COVID-19 as the disease model.
methodsLeghorn chickens were immunized with precipitated SARS-CoV-2 virus, and IgY antibodies were purified via ammonium sulfate precipitation and titrated by ELISA. Dot Blotting detected viral antigens in saliva samples, demonstrating efficacy comparable to ELISA tests.
resultsThe IgY antibody was successfully produced and purified, obtaining a titration of 1:16,000. The ability of IgY to detect SARS-CoV-2 in clinical saliva samples showed promising results in terms of accuracy (91.3%), sensitivity (92.5%), specificity (90.0%), positive predictive value (PPV) (90.2%), negative predictive value (NPV) (92.3%), and Cohen's Kappa (0.825).
conclusionChicken antibodies proved effective for early and accurate diagnosis of respiratory infections, including COVID-19. This study validates the efficacy of chicken antibodies in diagnosing respiratory infections, supporting pandemic response in developing nations. Expanding diagnostic capabilities is crucial for combating respiratory pathogens.
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