Evidence map›Paper›PMID 40823913›Full record

ArticleProtein science : a publication of the Protein Society2025

Unveiling the molecular mechanism of G

Baoyu He, Longfei Mao, Xiaojie Jin, Hongliang Duan, Jingjing Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein science : a publication of the Protein Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Unveiling the molecular mechanism of GProtein science : a publication of the Protein Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Baoyu HeFaculty of Applied Sciences, Macao Polytechnic University, Macao, China.
Longfei MaoCollege of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, China.
Xiaojie JinCollege of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, China.
Hongliang DuanFaculty of Applied Sciences, Macao Polytechnic University, Macao, China.
Jingjing GuoFaculty of Applied Sciences, Macao Polytechnic University, Macao, China.ORCID 0000-0002-4632-4364

Funding

Macao Polytechnic University RP/CAI-01/2022Macao Polytechnic University RP/CAI-01/2023
6 · The paper itself

Abstract

Metabotropic glutamate (mGlu) receptors play a crucial role in synaptic transmission through homodimeric or heterodimeric assemblies. Despite their dimeric nature, only one subunit within the mGlu dimer engages with G proteins during activation, and the biased activation can be further controlled by allosteric modulators. Considering the related molecular mechanisms remain elusive, we employed Gaussian accelerated molecular dynamics (GaMD) simulations to investigate the regulated mechanisms in mGlu

Indexed as

GTP-Binding Protein alpha Subunits, Gi-GoMolecular Dynamics SimulationReceptors, Metabotropic GlutamateAllosteric RegulationHumansProtein BindingProtein MultimerizationGTP-Binding Protein alpha Subunits, Gi-Gometabotropic glutamate receptor 2metabotropic glutamate receptor 4Receptors, Metabotropic Glutamateallosteric regulationgaussian accelerated molecular dynamics simulationsGPCRsmGlu2–mGlu4 heterodimersPAM

Identifiers

PMID40823913
PMCPMC12359205

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.