Evidence map›Paper›PMID 40823868›Full record

ArticleAntimicrobial agents and chemotherapy2025

Frequencies of molecular markers of drug resistance in the context of two different Seasonal Malaria Chemoprevention (SMC) treatment regimens in the Koulikoro health district, Mali.

Bourama Traore, Fousseyni Kane, Mahamoudou Toure, Marie Helene Munck Jørgensen, Daouda Sanogo, Soumba Keita, Moussa Keita, Nafomon Sogoba, Kathryn Shaw-Saliba, Mahamadou Diakite and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Bourama Traore *University Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
Fousseyni Kane *University Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.ORCID 0000-0002-9967-7956
Mahamoudou ToureUniversity Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
Marie Helene Munck JørgensenCentre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Daouda SanogoUniversity Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
Soumba KeitaUniversity Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
Moussa KeitaInfectious Diseases and Medical Entomology Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
Nafomon SogobaInfectious Diseases and Medical Entomology Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
Kathryn Shaw-SalibaCollaborative Clinical Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Mahamadou DiakiteUniversity Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
Jeffrey G ShafferSchool of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA.
Michael AlifrangisCentre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Helle Hansson *Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Seydou Doumbia *University Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.

Funding

H3ABioNet: informatics solutions for H3AfricaU24HG006941 · NHGRI · UNIVERSITY OF CAPE TOWN · PI MULDER, NICOLA · 2017 to 2021
$12.9M
Sequencing and Genomics CoresU19AI089696 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI KOITA, OUSMANE ALIOU · 2010 to 2016
$10.6M
Multidisciplinary Implementation Research for malaria control and elimination in West AfricaU19AI129387 · NIAID · UNIV OF SCIENCES, TECH & TECH OF BAMAKO · PI Mahamoudou Toure · 2017 to 2026
$8.2M
Training Program on Operational and Health Services Research for Malaria in MaliD43TW008652 · FIC · UNIV OF SCIENCES, TECH & TECH OF BAMAKO · PI SEYDOU DOUMBIA, Alexandre Delamou · 2010 to 2026
$3.1M
West African Center of Excellence for Global Health Bioinformatics Research TrainingU2RTW010673 · FIC · UNIV OF SCIENCES, TECH & TECH OF BAMAKO · PI DOUMBIA, SEYDOU, LI, JIAN · 2017 to 2021
$1.2M
West Africa Center of Excellence for Data Science Research EducationUE5TW012526 · FIC · UNIV OF SCIENCES, TECH & TECH OF BAMAKO · PI DOUMBIA, SEYDOU, SHAFFER, JEFFREY G · 2023 to 2025
$600k
American Society of Tropical Medicine and Hygiene Donald Krogstad Award for Early-Career Malian ScientistsFIC NIH HHS D43 TW008652FIC NIH HHS D43TW008652FIC NIH HHS U2R TW010673FIC NIH HHS U2RTW010673FIC NIH HHS UE5 TW012526National Institute of Allergy and Infectious Diseases U19AI089696, U19AI129387NHGRI NIH HHS U24 HG006941NIAID NIH HHS U19 AI089696NIAID NIH HHS U19 AI129387
6 · The paper itself

Abstract

With growing concern about parasite resistance to sulfadoxine-pyrimethamine (SP) in West Africa, the effectiveness of dihydroartemisinin-piperaquine (DHA + PQ) was assessed as an alternative drug regimen for Seasonal Malaria Chemoprevention (SMC). This study aims to determine the prevalence of molecular markers of resistance to SP + AQ and DHA + PQ in Koulikoro (Mali), where SMC has been implemented since 2014.

Indexed as

AntimalarialsDrug ResistanceMalaria, FalciparumPlasmodium falciparumArtemisininsAspartic Acid EndopeptidasesATP-Binding Cassette, Sub-Family C ProteinsChemopreventionDNA Copy Number VariationsDrug CombinationsHaplotypesHumansMaliMembrane Transport ProteinsPiperazinesPolymorphism, Single NucleotideAntimalarialsArtemisininsartenimolAspartic Acid EndopeptidasesATP-Binding Cassette, Sub-Family C ProteinsDrug Combinationsfanasil, pyrimethamine drug combinationMdr1 protein, Plasmodium falciparumMembrane Transport ProteinspiperaquinePiperazinesProtozoan ProteinsPyrimethamineQuinolinesSulfadoxineTetrahydrofolate Dehydrogenasedihydroartemisinin-piperaquineMaliPlasmodium falciparumSeasonal Malaria Chemopreventionsulfadoxine-pyrimethamine, amodiaquine

Identifiers

PMID40823868
PMCPMC12486799

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.