Evidence map›Paper›PMID 40823863›Full record

ArticleMicrobiology spectrum2025

Identification of strain-specific cues that regulate biofilm formation in

Robert W P Glowacki, Morgan J Engelhart, Jessica M Till, Anagha Kadam, Ina Nemet, Naseer Sangwan, Philip P Ahern

Abstract read
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Robert W P GlowackiDepartment of Cardiovascular and Metabolic Sciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.ORCID 0000-0001-7718-5056
Morgan J EngelhartDepartment of Cardiovascular and Metabolic Sciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.
Jessica M TillDepartment of Cardiovascular and Metabolic Sciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.
Anagha KadamDepartment of Cardiovascular and Metabolic Sciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.
Ina NemetDepartment of Cardiovascular and Metabolic Sciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.
Naseer SangwanDepartment of Cardiovascular and Metabolic Sciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.
Philip P AhernDepartment of Cardiovascular and Metabolic Sciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.ORCID 0000-0002-2083-3224

Funding

The Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Fabio Cominelli · 2015 to 2026
$15.6M
Unraveling strain-level variation in the induction of anti-inflammatory responses in the intestineR01DK126772 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI AHERN, PHILIP PATRICK · 2021 to 2025
$2.4M
Division of Loan Repayment LRP0000016021Division of Loan Repayment LRP0000045724NHLBI NIH HHS R01HL16074NIDDK NIH HHS P30 DK097948NIDDK NIH HHS R01 DK126772NIDDK NIH HHS R01DK126772
6 · The paper itself

Abstract

Members of the gut microbiome encounter a barrage of host- and microbe-derived microbiocidal factors that must be overcome to maintain fitness in the intestine. The long-term stability of many gut microbiome strains within the microbiome suggests the existence of strain-specific strategies that have evolved to foster resilience to such insults. Despite this, little is known about the mechanisms that mediate this resistance. Biofilm formation represents one commonly employed defense strategy against stressors like those found in the intestine. Here, we demonstrate strain-level variation in the capacity of the gut symbiont

Indexed as

Bacteroides thetaiotaomicronBiofilmsAcetic AcidBile Acids and SaltsFatty Acids, VolatileGastrointestinal MicrobiomeHumansLithocholic AcidSpecies SpecificitySymbiosisAcetic AcidBile Acids and SaltsFatty Acids, VolatileLithocholic Acidbile acidsbiofilmsmicrobiomeshort-chain fatty acids

Identifiers

PMID40823863
PMCPMC12502800

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.