ArticleMicrobiology spectrum2025
Multi-omics analysis reveals the host-microbe interactions on the dysbiosis of tissue microbiota in male genital lichen sclerosus-induced urethral strictures.
Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Pathological phimosis is associated with foreskin immune cell infiltration but not microbiota composition.mSphere · 2026Article
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Authors and funding
7 authors.
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Abstract
Male genital lichen sclerosus-induced urethral stricture is a chronic inflammatory disease with significant microbiota dysbiosis. However, dysbiosis inside lesion tissue and its correlation with gene expression in male genital lichen sclerosus (MGLSc) remain elusive. This study investigated the influence of host-microbe interactions on dysbiosis and differential gene expression in MGLSc. Microbiome and transcriptome sequencing were conducted using prepuce samples from 27 MGLSc patients and 17 controls. We also performed immunohistochemistry staining of bacterial markers on prepuce tissue from two cohorts. Furthermore, potential risk factor information available from the MGLSc clinical data was collected and correlated with the differential microbiota. Unclassified Muribaculaceae and IMPORTANCE: Our study combined full-length 16S rDNA sequencing, transcriptome data, and clinical information from MGLSc patients to explore the relationships between host-microbe interactions and the development of tissue dysbiosis in MGLSc. Importantly, through staining for lipopolysaccharide and lipoteichoic acid, as well as full-length 16S rDNA sequencing, we identified, for the first time, the presence of microorganisms distribution pattern in lichen sclerosus prepuce tissue. Significant differences in the abundance of unclassified Muribaculaceae,
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