Evidence map›Paper›PMID 40823842›Full record

ArticlemBio2025

Siderophore systems at play: system interactions as drivers of diversification in pathogenic

Marta A Lages, Lucía Ageitos, Larissa Buedenbender, Jaime Rodríguez, Manuel L Lemos, Carlos Jiménez, Miguel Balado

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marta A Lages *Department of Microbiology and Parasitology, Aquatic One Health Research Center (iARCUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Lucía Ageitos *CICA - Centro Interdisciplinar de Química e Bioloxía and Departamento de Química, Universidade da Coruña, A Coruña, Spain.
Larissa Buedenbender *CICA - Centro Interdisciplinar de Química e Bioloxía and Departamento de Química, Universidade da Coruña, A Coruña, Spain.
Jaime RodríguezCICA - Centro Interdisciplinar de Química e Bioloxía and Departamento de Química, Universidade da Coruña, A Coruña, Spain.ORCID 0000-0001-5348-6970
Manuel L LemosDepartment of Microbiology and Parasitology, Aquatic One Health Research Center (iARCUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.ORCID 0000-0001-7964-2089
Carlos JiménezCICA - Centro Interdisciplinar de Química e Bioloxía and Departamento de Química, Universidade da Coruña, A Coruña, Spain.ORCID 0000-0003-2628-303X
Miguel BaladoDepartment of Microbiology and Parasitology, Aquatic One Health Research Center (iARCUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.ORCID 0000-0002-5702-4631

Funding

HORIZON EUROPE Marie Sklodowska-Curie Actions 101066127Xunta de Galicia ED481B 2024/076
6 · The paper itself

Abstract

The IMPORTANCE: Iron acquisition is critical for bacterial survival and virulence, especially under the iron-limited conditions encountered in host environments. This study uncovers unexpected siderophore diversification within the piscibactin pathway, including two novel catecholate analogs and fluorinated derivatives produced via precursor-directed biosynthesis. We identify Irp5 as a versatile salicylate-activating enzyme that drives this metabolic flexibility. Moreover, the piscibactin and vanchrobactin systems interact at both biosynthetic and uptake levels, forming a resilient and adaptable iron acquisition network that supports virulence. These findings advance our understanding of siderophore-mediated iron acquisition and illustrate how enzymatic promiscuity and system interplay can be leveraged for synthetic biology and antimicrobial development. Given the widespread distribution of

Indexed as

SiderophoresVibrioBacterial ProteinsGenomic IslandsMetabolomicsTandem Mass SpectrometryVirulence FactorsBacterial ProteinsSiderophoresVirulence Factorsdiversificationgenomic islandsiderophoresiderophore metabolomeVibrio virulencevirulence evolution

Identifiers

PMID40823842
PMCPMC12421891

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.