Evidence map›Paper›PMID 40823840›Full record

ArticlemBio2025

Effects of simulated Martian environmental stressors on specific human pathogen-immune system interactions.

Tommaso Zaccaria, Özlem Bulut, Anaisa V Ferreira, Margo Dona, Jeroen D Langereis, Rob J Mesman, Joppe Wesseling, Laura van Niftrik, Mihai G Netea, Petra Rettberg and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tommaso Zaccaria *Aerospace Microbiology group, Department of Applied Aerospace Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.ORCID 0000-0002-3923-335X
Özlem Bulut *Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Anaisa V Ferreira *Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Margo DonaDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Jeroen D LangereisDepartment of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Center, Nijmegen, Netherlands.ORCID 0000-0001-5317-3202
Rob J MesmanDepartment of Microbiology, Faculty of Science, Radboud Institute for Biological and Environmental Sciences, Radboud University, Nijmegen, the Netherlands.
Joppe WesselingDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Laura van NiftrikDepartment of Microbiology, Faculty of Science, Radboud Institute for Biological and Environmental Sciences, Radboud University, Nijmegen, the Netherlands.
Mihai G NeteaDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Petra RettbergAstrobiology Research Group, Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.
Kristina Beblo-VranesevicAerospace Microbiology group, Department of Applied Aerospace Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.
Marien I de Jonge *Radboudumc Community for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0000-0003-2812-5895
Jorge Domínguez-Andrés *Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0000-0002-9091-1961

Funding

ERC Advanced 833247Off Road ZonMw 04510012010022Spinoza Grant
6 · The paper itself

Abstract

The identification of health risks associated with long-term crewed missions to Mars is critical for mission planning and crew safety. Human-associated pathogens can be part of the microbiome and are likely to be transported during these missions. This study examines the immunological responses of human immune cells stimulated with non-fastidious bacterial species that cause opportunistic infections, i.e., IMPORTANCE: Since Yuri Gagarin's 1961 flight, human space exploration has expanded, unintentionally transporting microorganisms, including pathogens, into space environments. Our previous studies demonstrated that opportunistic pathogens like

Indexed as

Extraterrestrial EnvironmentHost-Pathogen InteractionsKlebsiella pneumoniaeLeukocytes, MononuclearMarsSerratia marcescensStress, PhysiologicalCytokinesHumansPhagocytosisReactive Oxygen SpeciesSpace SimulationUltraviolet RaysCytokinesReactive Oxygen Speciesadaptive immunitybacterial survivalhuman pathogeninnate immunityKlebsiella pneumoniaeSerratia marcescensspace crew health

Identifiers

PMID40823840
PMCPMC12421960

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.