Evidence map›Paper›PMID 40823832›Full record

ArticlemBio2025

Loss of cardiolipin and porins bypasses the essentiality of the sigma E cell envelope stress response in

Zihao Yang, Emily C A Goodall, Bing Zhang, Von V L Torres, Jessica L Rooke, Karthik Pullela, Rochelle M Da Costa, Christopher Icke, Mark A T Blaskovich, Simon Legood and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. ModelingbioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zihao YangInstitute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Emily C A GoodallInstitute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Bing ZhangInstitute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Von V L TorresInstitute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Jessica L RookeInstitute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Karthik PullelaInstitute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Rochelle M Da CostaInstitute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Christopher IckeInstitute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Mark A T BlaskovichInstitute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Simon LegoodInstitute of Microbiology and Infection, University of Birmingham, Birmingham, England, United Kingdom.
Adam F CunninghamInstitute of Microbiology and Infection, University of Birmingham, Birmingham, England, United Kingdom.ORCID 0000-0003-0248-964X
Waldemar VollmerInstitute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Jack A BryantSchool of Life Sciences, University of Nottingham, Nottingham, England, United Kingdom.
Ian R HendersonInstitute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.ORCID 0000-0002-9954-4977

Funding

Department of Education and Training | Australian Research Council (ARC)University of Queensland Scholarship
6 · The paper itself

Abstract

The Gram-negative cell envelope is composed of an inner and outer membrane, each with different lipid compositions. The inner membrane is predominantly made up of phosphatidylglycerol, phosphatidylethanolamine, and cardiolipin, while the outer membrane contains the same lipids but has a predominantly lipopolysaccharide composition in the outer leaflet. The outer membrane forms a permeability barrier that blocks the entry of toxins and antibiotics; however, it is decorated with outer membrane proteins that allow nutrient uptake and the efflux of intracellular toxins. In

Indexed as

CardiolipinsCell MembraneEscherichia coliEscherichia coli ProteinsPorinsSigma FactorStress, PhysiologicalBacterial Outer Membrane ProteinsGene Expression Regulation, BacterialBacterial Outer Membrane ProteinsCardiolipinsEscherichia coli ProteinsPorinsSigma Factorsporulation-specific sigma factorscardiolipinE. coliphospholipidtradistransposon sequencing

Identifiers

PMID40823832
PMCPMC12421810

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.